Depth of invasion on pathological outcomes in clinical low‐stage oral tongue cancer patients

Objectives Depth of invasion was added to the eighth edition American Joint Committee on Cancer guidelines for T staging of HPV‐negative oral cavity squamous cell carcinoma. Our aim was to determine the impact of depth of invasion on pathological variables and outcomes in low‐stage tongue cancer pat...

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Bibliographic Details
Published in:Oral diseases 2018-10, Vol.24 (7), p.1198-1203
Main Authors: Masood, Maheer M., Farquhar, Douglas R., Vanleer, Jessica P., Patel, Samip N., Hackman, Trevor G.
Format: Article
Language:English
Subjects:
Adult
Aged
Biopsy
Blood Vessels - pathology
Cancer
cancer and precancer
Carcinoma, Squamous Cell - pathology
Carcinoma, Squamous Cell - secondary
Carcinoma, Squamous Cell - surgery
Dentistry
Disease-Free Survival
Female
Humans
Lymphatic Vessels - pathology
Male
Metastases
Middle Aged
Neck
Neoplasm Invasiveness
Neoplasm Metastasis
Neoplasm Recurrence, Local - pathology
Neoplasm Staging
oncology
Oral cancer
Oral cavity
otorhinolaryngology
Prognosis
Regression analysis
Squamous cell carcinoma
Tongue
Tongue Neoplasms - pathology
Tongue Neoplasms - surgery
Tumor Burden
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Summary:Objectives Depth of invasion was added to the eighth edition American Joint Committee on Cancer guidelines for T staging of HPV‐negative oral cavity squamous cell carcinoma. Our aim was to determine the impact of depth of invasion on pathological variables and outcomes in low‐stage tongue cancer patients. We also examine the impact of tumor thickness and tumor clinical staging for comparison. Subjects and Methods All clinical T1/T2 N0 HPV‐negative tongue squamous cell carcinoma patients who received elective neck dissections at our institution between 2000 and 2015 were included. Logistic regression models and Cox proportional hazard models were used to examine pathological variables, recurrence, and 3‐year disease‐free survival. Results Sixty‐seven patients met criteria; the mean age was 52.0 (SD: 17.7). Depth of invasion was a significant predictor of occult metastasis (OR: 2.0, p = 0.05) and lymphovascular invasion (OR: 4.1, p = 0.02), and tumor thickness was a significant predictor of lymphovascular invasion (OR: 3.3, p = 0.04). None of the variables were predictive of recurrence or disease‐free survival. Conclusion Depth of invasion at biopsy may be a potential useful metric to inform on regional management selection in this radiographic node‐negative population.
ISSN:1354-523X
1601-0825
DOI:10.1111/odi.12887