An operational definition of SHATS (Systemic Hemodynamic Atherosclerotic Syndrome): Role of arterial stiffness and blood pressure variability in elderly hypertensive subjects

CV risk exponentially increases as the number of damaged organs increases The Systemic Hemodynamic Atherosclerotic Syndrome (SHATS) represents a novel conceptualization of the CV continuum focusing on simultaneous multi-organ alteration. This is the first study operationally defining SHATS and aimed...

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Bibliographic Details
Published in:International journal of cardiology 2018-07, Vol.263, p.132-137
Main Authors: Scuteri, Angelo, Rovella, Valentina, Alunni Fegatelli, Danilo, Tesauro, Manfredi, Gabriele, Marco, Di Daniele, Nicola
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Arterial stiffness
Atherosclerosis - diagnosis
Atherosclerosis - epidemiology
Atherosclerosis - physiopathology
Blood Pressure - physiology
Blood pressure variability
Carotid Artery Diseases - diagnosis
Carotid Artery Diseases - epidemiology
Carotid Artery Diseases - physiopathology
Cross-Sectional Studies
Female
Hemodynamics - physiology
Humans
Hypertension - diagnosis
Hypertension - epidemiology
Hypertension - physiopathology
Hypertrophy, Left Ventricular - diagnosis
Hypertrophy, Left Ventricular - epidemiology
Hypertrophy, Left Ventricular - physiopathology
Male
Middle Aged
Multiple systemic organ alteration
Pulse wave velocity
Renal Insufficiency, Chronic - diagnosis
Renal Insufficiency, Chronic - epidemiology
Renal Insufficiency, Chronic - physiopathology
Syndrome
Target organ damage
Vascular Stiffness - physiology
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Summary:CV risk exponentially increases as the number of damaged organs increases The Systemic Hemodynamic Atherosclerotic Syndrome (SHATS) represents a novel conceptualization of the CV continuum focusing on simultaneous multi-organ alteration. This is the first study operationally defining SHATS and aimed at identifying its determinants. Left Ventricular Hypertrophy (echocardiography), Common Carotid Artery plaque and increased thickness (ultrasound), and Chronic Kidney Disease (estimated Glomerular Filtration Rate) indexed selective target organ damage. SHATS was operationally defined as their simultaneous presence in a patient. PWV was measured by Sphygmocor® and BP variability by 24 h ABPM. SHATS affected 19.9% of the 367 studied subjects. Subjects with SHATS had a similar prevalence in diabetes mellitus, but a greater prevalence of very stiff artery (84.9 vs 64.3%, p 
ISSN:0167-5273
1874-1754
DOI:10.1016/j.ijcard.2018.03.117