Incremental risk of long-term mortality with increased burden of comorbidity in hospitalized patients with pneumonia

Patients hospitalized for pneumonia often have concurrent comorbid conditions (CCs). The influence of CCs on the risk of subsequent death is not fully understood. We examined adults hospitalized for pneumonia between 1996 through 2015 at Mayo Clinic for the presence of 20 priori selected CCs. We est...

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Bibliographic Details
Published in:European journal of internal medicine 2018-09, Vol.55, p.23-27
Main Authors: Yousufuddin, Mohammed, Shultz, Jessica, Doyle, Taylor, Rehman, Hamid, Murad, Mohammad Hassan
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Cause of Death
Cohort Studies
Comorbidity
Female
Humans
Length of Stay - statistics & numerical data
Male
Middle Aged
Minnesota - epidemiology
Mortality
Multivariate Analysis
Pneumonia
Pneumonia - mortality
Prognosis
Risk Factors
Survival Analysis
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Summary:Patients hospitalized for pneumonia often have concurrent comorbid conditions (CCs). The influence of CCs on the risk of subsequent death is not fully understood. We examined adults hospitalized for pneumonia between 1996 through 2015 at Mayo Clinic for the presence of 20 priori selected CCs. We estimated cumulative all-cause mortality by number of CCs using multivariable Cox regression model. Study comprised of 9580 adults (age 70 ± 17.0 years, men 53%, whites 88%) with median number of CCs 3 (interquartile 1–4), and overall deaths 6032 (62.9%) during 50,934 person-years of follow up (118.5 deaths/1000 person-years). After adjustment, any single comorbid condition was associated with 9% greater risk of death (95% confidence interval 1.08–1.11, P 
ISSN:0953-6205
1879-0828
DOI:10.1016/j.ejim.2018.05.003