Impact of routine rotavirus vaccination on all-cause and rotavirus hospitalizations during the first four years following vaccine introduction in Rwanda

Rwanda introduced pentavalent rotavirus vaccine into its national immunization program in 2012. To determine the long-term impact of rotavirus vaccine on disease burden in a high burden setting, we examined trends in rotavirus and all-cause diarrhea hospitalizations in the first four years following...

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Bibliographic Details
Published in:Vaccine 2018-11, Vol.36 (47), p.7135-7141
Main Authors: Sibomana, Hassan, Rugambwa, Celse, Mwenda, Jason M., Sayinzoga, Felix, Iraguha, Gisele, Uwimana, Jeanine, Parashar, Umesh D., Tate, Jacqueline E.
Format: Article
Language:English
Subjects:
Age
Child, Preschool
Children
Diarrhea
Diarrhea - epidemiology
Diarrhea - prevention & control
Diarrhea - virology
Epidemiology
Gastroenteritis - epidemiology
Gastroenteritis - prevention & control
Gastroenteritis - virology
Hospitalization
Hospitalization - statistics & numerical data
Hospitalization - trends
Humans
Immunization
Immunization Programs
Infant
Information management
Information systems
Management information systems
Pediatrics
Population
Registries
Rotavirus
Rotavirus Infections - epidemiology
Rotavirus Infections - prevention & control
Rotavirus vaccine
Rotavirus Vaccines - therapeutic use
Rwanda
Rwanda - epidemiology
Surveillance
Trends
Vaccination
Vaccines
Viruses
World Health Organization
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Summary:Rwanda introduced pentavalent rotavirus vaccine into its national immunization program in 2012. To determine the long-term impact of rotavirus vaccine on disease burden in a high burden setting, we examined trends in rotavirus and all-cause diarrhea hospitalizations in the first four years following rotavirus vaccine introduction. We used data from an active surveillance system, from a review of pediatric ward registries, and from the Health Management Information System to describe trends in rotavirus and all-cause diarrhea hospitalizations from January 2009 through December 2016. Percent reductions were calculated to compare the number of all-cause and rotavirus diarrhea hospitalizations pre- and post-rotavirus vaccine introduction. The proportion of diarrhea hospitalizations due to rotavirus declined by 25–44% among all children
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2018.01.072