Brief communication: Age-dependent association of KIBRA genetic variation and Alzheimer's disease risk

An association between memory performance in healthy young, middle aged an elderly subjects and variability in the KIBRA gene (rs17070145) has been recently described. We analyzed this polymorphism in 391 sporadic Alzheimer's disease (AD) patients and 428 cognitively normal control subjects. Th...

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Bibliographic Details
Published in:Neurobiology of aging 2009-02, Vol.30 (2), p.322-324
Main Authors: Rodriguez-Rodriguez, Eloy, Infante, Jon, Llorca, Javier, Mateo, Ignacio, Sanchez-Quintana, Coro, Garcia-Gorostiaga, Ines, Sanchez-Juan, Pascual, Berciano, Jose, Combarros, Onofre
Format: Article
Language:English
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Summary:An association between memory performance in healthy young, middle aged an elderly subjects and variability in the KIBRA gene (rs17070145) has been recently described. We analyzed this polymorphism in 391 sporadic Alzheimer's disease (AD) patients and 428 cognitively normal control subjects. The current study reveals that KIBRA (rs17070145) T allele (CT and TT genotypes) is associated with an increased risk (OR 2.89; p = 0.03) for very-late-onset (after the age of 86 years) AD.
ISSN:0197-4580
DOI:10.1016/j.neurobiolaging.2007.07.003