Brief communication: Age-dependent association of KIBRA genetic variation and Alzheimer's disease risk

An association between memory performance in healthy young, middle aged an elderly subjects and variability in the KIBRA gene (rs17070145) has been recently described. We analyzed this polymorphism in 391 sporadic Alzheimer's disease (AD) patients and 428 cognitively normal control subjects. Th...

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Published in:Neurobiology of aging 2009-02, Vol.30 (2), p.322-324
Main Authors: Rodriguez-Rodriguez, Eloy, Infante, Jon, Llorca, Javier, Mateo, Ignacio, Sanchez-Quintana, Coro, Garcia-Gorostiaga, Ines, Sanchez-Juan, Pascual, Berciano, Jose, Combarros, Onofre
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container_issue 2
container_start_page 322
container_title Neurobiology of aging
container_volume 30
creator Rodriguez-Rodriguez, Eloy
Infante, Jon
Llorca, Javier
Mateo, Ignacio
Sanchez-Quintana, Coro
Garcia-Gorostiaga, Ines
Sanchez-Juan, Pascual
Berciano, Jose
Combarros, Onofre
description An association between memory performance in healthy young, middle aged an elderly subjects and variability in the KIBRA gene (rs17070145) has been recently described. We analyzed this polymorphism in 391 sporadic Alzheimer's disease (AD) patients and 428 cognitively normal control subjects. The current study reveals that KIBRA (rs17070145) T allele (CT and TT genotypes) is associated with an increased risk (OR 2.89; p = 0.03) for very-late-onset (after the age of 86 years) AD.
doi_str_mv 10.1016/j.neurobiolaging.2007.07.003
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title Brief communication: Age-dependent association of KIBRA genetic variation and Alzheimer's disease risk
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