Niacin modulates macrophage polarization in Parkinson's disease

Neuroinflammation remains a central piece in Parkinson's disease (PD) pathophysiology. However, mechanisms by which PD links to the neuroinflammation remain elusive. Here, for the first time, we report that lower dose of niacin in PD patients may affect macrophage polarization from M1 (pro-infl...

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Bibliographic Details
Published in:Journal of neuroimmunology 2018-07, Vol.320, p.76-79
Main Authors: Wakade, Chandramohan, Giri, Banabihari, Malik, Aneeq, Khodadadi, Hesam, Morgan, John C., Chong, Raymond K., Baban, Babak
Format: Article
Language:English
Subjects:
GPR109A
Macrophage polarization
Niacin
Parkinson's disease
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Summary:Neuroinflammation remains a central piece in Parkinson's disease (PD) pathophysiology. However, mechanisms by which PD links to the neuroinflammation remain elusive. Here, for the first time, we report that lower dose of niacin in PD patients may affect macrophage polarization from M1 (pro-inflammatory) to M2 (counter-inflammatory) profile through the niacin receptor GPR109A. Skew in the peripheral macrophages were accompanied by improved quality of life assessments in patients. Low dose niacin supplementation may be beneficial in PD, boosting anti-inflammatory processes and suppressing inflammation. Varied niacin dosages for longer durations may further reveal the potential role of anti-inflammatory interventions in PD progression. [Display omitted]
ISSN:0165-5728
1872-8421
DOI:10.1016/j.jneuroim.2018.05.002