Tumour volume of resectable oesophageal squamous cell carcinoma measured with MRI correlates well with T category and lymphatic metastasis

• Published in: European radiology 2018-11, Vol.28 (11), p.4757-4765
• Main Authors: Wu, Lan, Ou, Jing, Chen, Tian-wu, Li, Rui, Zhang, Xiao-ming, Chen, Yan-li, Jiang, Yu, Yang, Jian-qiong, Cao, Jin-ming
• Format: Article
• Language: English
• Subjects: Aged; Analysis of Variance; Correlation analysis; Diagnostic Radiology; Diffusion Magnetic Resonance Imaging; Esophageal cancer; Esophageal Squamous Cell Carcinoma - diagnostic imaging; Esophageal Squamous Cell Carcinoma - pathology; Esophagus; Female; Gastrointestinal; Humans; Imaging; Internal Medicine; Interventional Radiology; Kruskal-Wallis test; Lymphatic Metastasis - pathology; Magnetic resonance imaging; Magnetic Resonance Imaging - methods; Male; Medical imaging; Medicine; Medicine & Public Health; Metastases; Metastasis; Middle Aged; Neoplasm Staging - methods; Neuroradiology; Radiology; ROC Curve; Squamous cell carcinoma; Statistical analysis; Tumor Burden; Tumors; Ultrasound; Variance analysis
• ISSN: 0938-7994; 1432-1084
• DOI: 10.1007/s00330-018-5477-0

Objectives To determine association of gross tumour volume (GTV) of resectable oesophageal squamous cell carcinoma (SCC) measured on T 2 -weighted imaging (T 2 WI), contrast-enhanced T 1 -weighted imaging (CE-T 1 WI) and diffusion-weighted imaging (DWI) with T category and lymphatic metastasis (LM). Methods Sixty oesophageal SCC patients underwent fat-suppressed T 2 WI, CE-T 1 WI and DWI with b values of 0, 500 and 800 s/mm 2 . GTV was measured on three sequences. Statistical analyses were performed to determine association of GTV with T category and LM. Results Spearman's rank correlation analysis showed positive association of GTV with T category and LM (all p values < 0.01). Differences in GTV were found between T1 and T2 or T3 categories shown by Kruskal-Wallis H and one-way ANOVA tests, and between T1/T2 and T3 and between tumours with and without LM by Mann-Whitney U tests (all p values < 0.05). Receiver operating characteristic analyses showed cut-off GTVs of 5.795, 5.276 and 10.11 cm 3 on CE-T 1 WI could better differentiate T1 from T2 categories, T1 from T3, and T1-2 from T3 than those of 7.066, 7.045 and 8.504 cm 3 on T 2 WI, of 5.793, 6.609 and 6.989 cm 3 on DWI with b value of 500 s/mm 2 , and of 4.156, 4.519 and 4.985 cm 3 with b value of 800 s/mm 2 , respectively. Cut-off of 10.462 cm 3 on DWI with b value of 500 s/mm 2 could better identify LM than of 12.38, 8.793 and 9.600 cm 3 on T 2 WI, CE-T 1 WI and DWI with b value of 800 s/mm 2 , respectively. Conclusions GTVs on T 2 WI, CE-T 1 WI and DWI are associated with T category of and LM of oesophageal SCC. Key Points • GTV is associated with T category and lymphatic metastasis of oesophageal SCC • GTV measured on contrast-enhanced T 1 -weighted imaging better identifies T category • GTV measured on DWI with b value of 500 s/mm 2 better identifies lymphatic metastasis