Aggregation kinetics of the Aβ1-40 peptide monitored by NMR

The aggregation of Aβ1-40 was monitored by solution NMR, which showed a trend complementary to the one observed by ThT-fluorescence. The NMR data support a kinetic model where Aβ1-40 initially aggregates with the reversible formation of oligomeric species, which then irreversibly convert into fibril...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2018, Vol.54 (55), p.7601-7604
Main Authors: Bellomo, Giovanni, Bologna, Sara, Gonnelli, Leonardo, Ravera, Enrico, Fragai, Marco, Lelli, Moreno, Luchinat, Claudio
Format: Article
Language:English
Subjects:
Agglomeration
Fluorescence
NMR
Nuclear magnetic resonance
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Summary:The aggregation of Aβ1-40 was monitored by solution NMR, which showed a trend complementary to the one observed by ThT-fluorescence. The NMR data support a kinetic model where Aβ1-40 initially aggregates with the reversible formation of oligomeric species, which then irreversibly convert into fibrils.
ISSN:1359-7345
1364-548X
DOI:10.1039/c8cc01710g