Prognostic factors in primary anorectal melanoma: a clinicopathological study of 60 cases in China

• Published in: Human pathology 2018-09, Vol.79, p.77-85
• Main Authors: Ren, Min, Lu, Yawen, Lv, Jiaojie, Shen, Xuxia, Kong, Jincheng, Dai, Bo, Kong, Yunyi
• Format: Article
• Language: English
• Subjects: Anorectal melanoma; Cancer; Clinicopathological feature; Disease-specific survival; Gangrene; Immunohistochemistry; Lymphatic system; Lymphocytes; Medical prognosis; Melanoma; Metastasis; Multivariate analysis; Prognostic factor; Survival analysis
• ISSN: 0046-8177; 1532-8392
• DOI: 10.1016/j.humpath.2018.05.004

To investigate the clinicopathological features and prognostic factors of primary anorectal melanoma, we described the clinical presentations, histopathology, and prognosis of 60 cases in China. Patients' age ranged from 17 to 86 years, with a female-to-male ratio of 2.33:1. The prevalent anatomic site of tumor was the anorectum. The mean tumor thickness was 11.5 mm, and mean tumor size was 2.9 cm. Abdominoperineal resection was performed on 38 (63.3%) patients, whereas wide local excision was performed on 22 (36.7%) patients. Thirty-three (55.0%) patients were pathologically confirmed to have lymph node metastasis, and 9 (15%) patients had clinically distant metastasis at diagnosis. Histologically, epithelioid cell (91.7%) was the predominant cell type, followed by spindle (31.7%), pleomorphic (25.0%), and small round cell (5.0%). Solid sheet, nest, pseudopapillary, and pseudoalveolar growth patterns were noted in 45 (75.0%), 22 (36.7%), 13 (21.7%), and 6 (10.0%) cases, respectively. After a median follow-up of 44 months, the 5-year disease-specific survival rate was 33.3%. Age, tumor size, depth of invasion, tumor thickness, lymphatic metastasis, and lymphovascular and perineural invasion were significantly correlated with survival in univariate analysis. Multivariate analysis revealed that age greater than 70 years and tumor invasion beyond deep muscular layer/sphincter ani externus were independent poor prognostic factors. As the largest single-institution study of anorectal melanoma in an Asian population, we concluded that anorectal melanoma is a rare and lethal malignant neoplasm with morphologic diversity. Large population–based studies are still needed to establish an efficient staging system in evaluation of prognosis and facilitation of treatment for anorectal melanoma patients. •Anorectal melanoma is a rare malignant neoplasm with morphologic diversity.•Age and depth of invasion are independent poor prognostic factors.•Lymphatic metastasis and tumor thickness are crucial prognostic factors.•T category thresholds of cutaneous melanoma are not applicable to anorectal melanoma.•More specific and precise staging system is needed for anorectal melanoma.