IgG4-Associated Adrenalitis—a Case Report

A 67-year-old man was adrenalectomized due to a tumor measuring 100 mm. Specimens revealed an inflammation with slight fibrosis and moderate infiltrates of lymphocytes and plasmacytes with immunoreactivity for IgG and IgG4 resulting in the diagnosis of an active IgG4-associated adrenalitis. To our k...

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Bibliographic Details
Published in:Endocrine pathology 2018-09, Vol.29 (3), p.294-298
Main Authors: Saeger, Wolfgang, Lohe, Bernd, Engels, Christina Luise, Werner, Ulrike
Format: Article
Language:English
Subjects:
Adrenal Gland Diseases - pathology
Aged
Case reports
Endocrinology
Fibrosis
Granuloma, Plasma Cell - pathology
Humans
Immunoglobulin G
Immunoglobulin G4-Related Disease - pathology
Immunoreactivity
Lymphocytes
Male
Medicine
Medicine & Public Health
Oncology
Pathology
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Summary:A 67-year-old man was adrenalectomized due to a tumor measuring 100 mm. Specimens revealed an inflammation with slight fibrosis and moderate infiltrates of lymphocytes and plasmacytes with immunoreactivity for IgG and IgG4 resulting in the diagnosis of an active IgG4-associated adrenalitis. To our knowledge, this is the first reported active adrenalitis of this type. It should be the precursor lesion of the adrenal calcifying fibrous tumor that was reported once before.
ISSN:1046-3976
1559-0097
DOI:10.1007/s12022-018-9531-x