Bisphenol-A and chlorinated derivatives in adipose tissue of women

Bisphenol-A (BPA) and chlorinated derivatives (Cl x BPA) were investigated in adipose tissue of women in Southeast Spain. BPA was above limit of detection (LOD) in 11 out of 20 samples (55%). Among Cl x BPA, Cl 2BPA was the most frequent (80%) and abundant, constituting 94.6% of total chlorinated BP...

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Bibliographic Details
Published in:Reproductive toxicology (Elmsford, N.Y.) N.Y.), 2007-08, Vol.24 (2), p.259-264
Main Authors: Fernandez, M.F., Arrebola, J.P., Taoufiki, J., Navalón, A., Ballesteros, O., Pulgar, R., Vilchez, J.L., Olea, N.
Format: Article
Language:English
Subjects:
Adipose tissue
Adipose Tissue - chemistry
Adult
Age Factors
Aged
Benzhydryl Compounds - analysis
Benzhydryl Compounds - chemistry
Biological and medical sciences
Bisphenol-A
Bisphenol-A chlorinated derivatives
Body Mass Index
Chlorophenols - analysis
Chlorophenols - chemistry
Embryology: invertebrates and vertebrates. Teratology
Environmental Exposure - analysis
Estrogens, Non-Steroidal - analysis
Estrogens, Non-Steroidal - chemistry
Female
Fundamental and applied biological sciences. Psychology
Gas Chromatography-Mass Spectrometry - methods
Humans
Medical sciences
Middle Aged
Molecular Structure
Overweight
Phenols - analysis
Phenols - chemistry
Polychlorinated Biphenyls - analysis
Polychlorinated Biphenyls - chemistry
Reproducibility of Results
Spain
Teratology. Teratogens
Toxicology
Women exposure
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Summary:Bisphenol-A (BPA) and chlorinated derivatives (Cl x BPA) were investigated in adipose tissue of women in Southeast Spain. BPA was above limit of detection (LOD) in 11 out of 20 samples (55%). Among Cl x BPA, Cl 2BPA was the most frequent (80%) and abundant, constituting 94.6% of total chlorinated BPA in adipose tissue. Mean ± S.D. of BPA, monochloro-BPA (ClBPA), dichloro-BPA (Cl 2BPA), and trichloro-BPA (Cl 3BPA) were 5.83 ± 3.48, 3.05 ± 0.28, 9.21 ± 9.26, and 0.74 ± 0.15 ng/g of adipose tissue, respectively. No tetrachloro-BPA (Cl 4BPA) was found above LOD. There are no published data on BPA in human adipose tissue or on Cl x BPA in adipose tissue or blood, limiting comparisons. BPA levels were similar (w/w) to findings in blood (w/v) in other populations and below levels reported in placenta tissue (w/w). Because of the estrogen mimicking effects of BPA and its Cl x BPA, further research is needed to explore their combined effects on human health and trends in human exposure.
ISSN:0890-6238
1873-1708
DOI:10.1016/j.reprotox.2007.06.007