Cutaneous complications among i.v. buprenorphine users

ABSTRACT i.v. buprenorphine hydrochloride (Subutex) misuse has been creating a number of medical complications, and cutaneous manifestations such as soft tissue infection are one of the commonest consequences. Between January 2004 and December 2006, amongst 130 i.v. buprenorphine abusers who present...

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Bibliographic Details
Published in:Journal of dermatology 2009-01, Vol.36 (1), p.22-29
Main Authors: HO, Roger C. M., HO, Emily C. L., MAK, Anselm
Format: Article
Language:English
Subjects:
Abscess - etiology
Adult
buprenorphine
Buprenorphine - administration & dosage
Buprenorphine - adverse effects
Cellulitis - etiology
cutaneous complications
Female
Humans
i.v. drug abuse
Injections, Intravenous
Male
Methicillin-Resistant Staphylococcus aureus
Middle Aged
Narcotic Antagonists - administration & dosage
Narcotic Antagonists - adverse effects
Opioid-Related Disorders - drug therapy
Singapore
Skin Diseases - etiology
Skin Diseases, Bacterial - etiology
Staphylococcal Infections - etiology
Staphylococcus aureus
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Summary:ABSTRACT i.v. buprenorphine hydrochloride (Subutex) misuse has been creating a number of medical complications, and cutaneous manifestations such as soft tissue infection are one of the commonest consequences. Between January 2004 and December 2006, amongst 130 i.v. buprenorphine abusers who presented to the National University Hospital, Singapore, cutaneous complications were identified in 45 patients (prevalence, 31%) with cellulitis and skin abscess being the commonest complications. Tissue and blood culture were positive in 19 (42%) patients and Methicillin‐sensitive Staphylococcus aureus was the commonest microbiological isolate (20%). Univariate linear regression revealed significant relationships between body temperature (P = 0.03), heart rate (P = 0.02), respiratory rate (P 
ISSN:0385-2407
1346-8138
DOI:10.1111/j.1346-8138.2008.00581.x