Mechlorethamine, procarbazine and prednisone for the treatment of resistant lymphoma in dogs

Forty-one dogs with resistant lymphoma were treated with a modified MOPP (mechlorethamine, vincristine, procarbazine and prednisone) protocol (MPP [mechlorethamine, procarbazine and prednisone] administered on a 21-day cycle, shortened from the 28-day MOPP cycle). The overall response rate to MPP wa...

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Bibliographic Details
Published in:Veterinary & comparative oncology 2009-03, Vol.7 (1), p.38-45
Main Authors: Northrup, N.C, Gieger, T.L, Kosarek, C.E, Saba, C.F, LeRoy, B.E, Wall, T.M, Hume, K.R, Childress, M.O, Keys, D.A
Format: Article
Language:English
Subjects:
adverse effects
Animals
antineoplastic agents
Antineoplastic Agents - administration & dosage
Antineoplastic Agents - adverse effects
Antineoplastic Agents, Alkylating - administration & dosage
Antineoplastic Agents, Alkylating - adverse effects
Antineoplastic Agents, Hormonal - administration & dosage
Antineoplastic Agents, Hormonal - adverse effects
Antineoplastic Combined Chemotherapy Protocols - administration & dosage
Antineoplastic Combined Chemotherapy Protocols - adverse effects
canine
chemotherapy
combination drug therapy
dog diseases
Dog Diseases - blood
Dog Diseases - drug therapy
Dog Diseases - pathology
Dogs
drug mixtures
Drug Resistance, Neoplasm
drug toxicity
Female
Georgia
lymphoma
Lymphoma - blood
Lymphoma - drug therapy
Lymphoma - pathology
Lymphoma - veterinary
lymphosarcoma
Male
mechlorethamine
Mechlorethamine - administration & dosage
Mechlorethamine - adverse effects
prednisone
Prednisone - administration & dosage
Prednisone - adverse effects
procarbazine
Procarbazine - administration & dosage
Procarbazine - adverse effects
Remission Induction - methods
rescue
Treatment Outcome
vincristine
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Summary:Forty-one dogs with resistant lymphoma were treated with a modified MOPP (mechlorethamine, vincristine, procarbazine and prednisone) protocol (MPP [mechlorethamine, procarbazine and prednisone] administered on a 21-day cycle, shortened from the 28-day MOPP cycle). The overall response rate to MPP was 34% for a median of 56 days (95% confidence interval 30-238). Seventeen percent of dogs had a complete response for a median duration of 238 days, 17% had a partial response for a median of 56 days and 32% had stable disease for a median of 24 days. Histological grade or cell morphology on cytology was associated with response. Minimal toxicity was observed with the MPP protocol, suggesting that further dose intensification or addition of another chemotherapeutic agent would be possible.
ISSN:1476-5810
1476-5829
DOI:10.1111/j.1476-5829.2008.00170.x