Vitamin K and Sphingolipid Metabolism: Evidence to Date

The brain is enriched with sphingolipids, which are important membrane constituents and major lipid signaling molecules that have a role in motor and cognitive behavior. Vitamin K has been implicated in brain sphingolipid metabolism for more than 30 years. The in vitro and in vivo studies to date su...

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Bibliographic Details
Published in:Nutrition reviews 2005-04, Vol.63 (4), p.111-121
Main Authors: Denisova, Natalia A, Booth, Sarah L
Format: Article
Language:English
Online Access:Get full text
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Summary:The brain is enriched with sphingolipids, which are important membrane constituents and major lipid signaling molecules that have a role in motor and cognitive behavior. Vitamin K has been implicated in brain sphingolipid metabolism for more than 30 years. The in vitro and in vivo studies to date suggest a role of vitamin K in the regulation of multiple enzymes involved in sphingolipid metabolism within the myelin-rich regions in the brain. However, the precise mechanisms of action are not well understood. Further, the physiological consequences of the observed effects of vitamin K on sphingolipid metabolism have not been systematically studied.
ISSN:0029-6643
DOI:10.1301/nr.2005.apr.111-121