Ertapenem – a potent treatment for clinical and quality of life improvement in patients with hidradenitis suppurativa

• Published in: International journal of dermatology 2018-09, Vol.57 (9), p.1088-1093
• Main Authors: Braunberger, Taylor L., Nartker, Nathan T., Nicholson, Cynthia L., Nahhas, Amanda F., Parks‐Miller, Angela, Hanna, Zachary, Jayaprakash, Rachna, Ramesh, Mayur S., Rambhatla, Pranita V., Hamzavi, Iltefat H.
• Format: Article
• Language: English
• Subjects: Administration, Intravenous; Adult; Anti-Bacterial Agents - administration & dosage; Anti-Bacterial Agents - therapeutic use; Drug Therapy, Combination; Ertapenem; Ertapenem - administration & dosage; Ertapenem - therapeutic use; Female; Females; Hidradenitis Suppurativa - drug therapy; Humans; Intravenous administration; Male; Males; Patient Satisfaction; Patients; Quality of Life; Recurrence; Retreatment; Retrospective Studies; Severity of Illness Index; Surgery; Therapy
• ISSN: 0011-9059; 1365-4632
• DOI: 10.1111/ijd.14036

Background A paucity of knowledge exists regarding the use of ertapenem in hidradenitis suppurativa. Our retrospective chart review and telephone interview aims to investigate the utility of intravenous ertapenem in severe, refractory hidradenitis suppurativa. Methods This retrospective chart review and telephone interview included patients with severe, refractory hidradenitis suppurativa treated with intravenous ertapenem between March 2013 and December 2016. Data were obtained from medical charts. During the telephone interview, patients were asked questions relating to satisfaction, quality of life changes, and disease state changes with ertapenem therapy. Results A total of 36 patients including 22 females and 14 males with Hurley stage II or III hidradenitis suppurativa were included. Thirty‐five patients (97.2%), demonstrated improvements in hidradenitis suppurativa with ertapenem treatment. In total, 28 patients participated in our telephone interview. Twenty patients (71.4%) were very satisfied (n = 12) or satisfied (n = 8). Quality of life improved in 85.7% of patients (n = 24). Conclusion Following ertapenem therapy, patients reported improvements in quality of life. This treatment appears promising as an adjunct to biologics or as a bridge to surgery in the treatment of severe, refractory hidradenitis suppurativa.