Environmental Toxins and Male Fertility

Purpose of Review Global industrialization has increased population exposure to environmental toxins. A global decline in sperm quality over the last few decades raises questions about the adverse impact of environmental toxins on male reproductive health. Recent Findings Multiple animal- and human-...

Full description

Saved in:
Bibliographic Details
Published in:Current urology reports 2018-07, Vol.19 (7), p.50-50, Article 50
Main Authors: Mima, Mahmoud, Greenwald, David, Ohlander, Samuel
Format: Article
Language:English
Subjects:
Environmental Pollutants - adverse effects
Epigenesis, Genetic
Hazardous Substances - adverse effects
Humans
Infertility, Male - etiology
Male
Medicine
Medicine & Public Health
Nephrology
rology and Infertility (L Lipshultz
Section Editor
Semen Analysis
Sperm Count
Spermatogenesis
Topical Collection on Andrology and Infertility
Urology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Purpose of Review Global industrialization has increased population exposure to environmental toxins. A global decline in sperm quality over the last few decades raises questions about the adverse impact of environmental toxins on male reproductive health. Recent Findings Multiple animal- and human-based studies on exposure to environmental toxins suggest a negative impact on semen quality, in terms of sperm concentration, motility, and/or morphology. These toxins may exert estrogenic and/or anti-androgenic effects, which in turn alter the hypothalamic-pituitary-gonadal axis (HPGA), induce sperm DNA damage, or cause sperm epigenetic changes. Summary This chapter will discuss the most recent literature about the most common environmental toxins and their impact on spermatogenesis and its consequences on male fertility. Understanding the presence and underlying mechanism of these toxins will help us preserve the integrity of the male reproduction system and formulate better regulations against their indiscriminate use.
ISSN:1527-2737
1534-6285
DOI:10.1007/s11934-018-0804-1