IL-33/s-ST2 ratio, systemic symptoms, and basophil activation in Pru p 3-sensitized allergic patients

Background Although IL-33 /ST2 axis is involved in the development of allergic diseases, its contribution in food allergy is still unknown. Methods In this study, we assessed the serum levels of IL-33 and its s-ST2 receptor in 53 control patients (without allergic diseases), 47 peach (Pru p 3)-sensi...

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Bibliographic Details
Published in:Inflammation research 2018-08, Vol.67 (8), p.671-679
Main Authors: Uasuf, Carina G., Sano, Caterina Di, Gangemi, Sebastiano, Albeggiani, Giuseppe, Cigna, Diego, Dino, Paola, Brusca, Ignazio, Gjomarkaj, Mark, Pace, Elisabetta
Format: Article
Language:English
Subjects:
Allergens
Allergic diseases
Allergology
Asthma
Biomedical and Life Sciences
Biomedicine
Blood
Cytokines
Dermatology
Exposure
Food allergies
Immunology
Inflammation
Lipids
Neurology
Original Research Paper
Patients
Pharmacology/Toxicology
Proteins
R&D
Research & development
Respiratory diseases
Rheumatology
Rhinitis
Serum levels
Steroids
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Summary:Background Although IL-33 /ST2 axis is involved in the development of allergic diseases, its contribution in food allergy is still unknown. Methods In this study, we assessed the serum levels of IL-33 and its s-ST2 receptor in 53 control patients (without allergic diseases), 47 peach (Pru p 3)-sensitized allergic patients (SAP), and in 68 non-Pru p 3-SAP. Basophil activation test (BAT) was used to assess the basophil activation due to allergen exposure before and after the addition of s-ST2 to the blood samples from 5 Pru p 3-SAP. Results IL-33 levels in Pru p 3-SAP were higher than in non-Pru p 3-SAP and in normal controls. Lower s-ST2 levels were found in Pru p 3-SAP than in non-Pru p 3-SAP. IL-33/s-ST2 ratio was higher in Pru p 3-SAP than in both non-Pru p 3-SAP and controls. Higher IL-33/s-ST2 ratio was observed in Pru p 3-SAP with severe than in those with mild systemic symptoms. BAT analysis in Pru p 3-SAP showed a decrease in basophil activation due to Pru p 3 exposure after the addition of s-ST2 to the blood samples. Conclusions An imbalance in the baseline levels of IL-33 / ST2 pathway is present in Pru p 3-SAP. The measurement of this pathway might be helpful to detect patients at a higher risk of developing severe systemic symptoms.
ISSN:1023-3830
1420-908X
DOI:10.1007/s00011-018-1157-4