Folate treatment of pregnant rat dams abolishes metabolic effects in female offspring induced by a paternal pre-conception unhealthy diet

Aims/hypothesis Paternal high-fat diet prior to mating programmes impaired glucose tolerance in female offspring. We examined whether the metabolic consequences in offspring could be abolished by folate treatment of either the male rats before mating or the corresponding female rats during pregnancy...

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Bibliographic Details
Published in:Diabetologia 2018-08, Vol.61 (8), p.1862-1876
Main Authors: Li, Jian, Lu, Yong-Ping, Tsuprykov, Oleg, Hasan, Ahmed A., Reichetzeder, Christoph, Tian, Mei, Zhang, Xiao Li, Zhang, Qin, Sun, Guo-Ying, Guo, Jingli, Gaballa, Mohamed M. S., Peng, Xiao-Ning, Lin, Ge, Hocher, Berthold
Format: Article
Language:English
Subjects:
Animal Feed
Animal Nutritional Physiological Phenomena
Animals
Beta cells
Body length
Cell density
CpG islands
Diet, High-Fat - adverse effects
Dietary supplements
DNA Methylation
Female
Females
Folic acid
Folic Acid - therapeutic use
Gene expression
Gene Expression Profiling
Glucose metabolism
Glucose tolerance
Glucose Tolerance Test
High fat diet
Human Physiology
Internal Medicine
Liver
Liver - embryology
Liver - metabolism
Male
Mating
Medicine
Medicine & Public Health
Metabolic Diseases
Metabolism
Offspring
Pancreas
Pancreas - metabolism
Pregnancy
Pregnancy, Animal
Rats
Rats, Sprague-Dawley
RNA - analysis
Rodents
Sodium Chloride - chemistry
Spermatogenesis
Sucrose
Sucrose - chemistry
Triglycerides - metabolism
Up-Regulation
Vitamin B
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Summary:Aims/hypothesis Paternal high-fat diet prior to mating programmes impaired glucose tolerance in female offspring. We examined whether the metabolic consequences in offspring could be abolished by folate treatment of either the male rats before mating or the corresponding female rats during pregnancy. Methods Male F0 rats were fed either control diet or high-fat, high-sucrose and high-salt diet (HFSSD), with or without folate, before mating. Male rats were mated with control-diet-fed dams. After mating, the F0 dams were fed control diet with or without folate during pregnancy. Results Male, but not female offspring of HFSSD-fed founders were heavier than those of control-diet-fed counterparts ( p  
ISSN:0012-186X
1432-0428
DOI:10.1007/s00125-018-4635-x