Cerebral and pulmonary nocardiosis to Nocardia abscessus in an immunocompetent Algerian patient

• Published in: Journal de mycologie médicale 2018-09, Vol.28 (3), p.531-537
• Main Authors: Arrache, D, Zait, H, Rodriguez-Nava, V, Bergeron, E, Durand, T, Yahiaoui, M, Grenouillet, F, Amrane, A, Chaouche, F, Baiod, A, Madani, K, Hamrioui, B
• Format: Article
• Language: fre
• Subjects: Adult; Algeria; Brain Abscess - diagnosis; Brain Abscess - microbiology; Humans; Immunocompetence; Lung Diseases, Fungal - diagnosis; Lung Diseases, Fungal - immunology; Male; Nocardia - isolation & purification; Nocardia Infections - diagnosis; Nocardia Infections - immunology
• ISSN: 1773-0449
• DOI: 10.1016/j.mycmed.2018.04.010

Nocardial brain abscess is often occurring in immunocompromised patients. It is uncommon in immunocompetent individuals. Here, the authors describe a case of cerebral and pulmonary nocardiosis mimicking a metastatic tumor in an apparently health 40-year-old Algerian male. The patient presented multiple brain abscess revealed by inaugural epileptic seizure. He was afebrile and presented with left hemiparesis. Staging imaging showed a nodular lung lesion in the apical segment of the right lower lobe. The patient underwent double craniotomy for resection of the lesion. Culture of the resected specimen isolated Nocardia abscessus. The patient was initially started on intravenous trimethoprim-sulfamethoxazole and intravenous amikacine. He was switched to oral trimethoprim-sulfamethoxazole. He finished seven months of antibiotic therapy with a good clinical response. Imaging revealed reduction in the brain abscess and a complete resolution of the lung lesion. Cotrimoxazole was stopped after twelve months of therapy. After two years, the health status of our patient improves day after day. He is however regularly under medical supervision for control exams.