Enhanced central venous catheter bundle for pediatric parenteral-dependent intestinal failure

• Published in: American journal of infection control 2018-11, Vol.46 (11), p.1284-1289
• Main Authors: Ormsby, Jennifer A., Bukoye, Bola, Lajoie, Debra, Shermont, Herminia, Martin, Lisa, Leger, Kierrah, Mahoney, Judy, Potter-Bynoe, Gail, Carpenter, Jane, Ozonoff, Al, Lee, Grace M.
• Format: Article
• Language: English
• Subjects: bundle; Central line–associated bloodstream infections; central venous catheter; intestinal failure; parenteral nutrition; quality improvement
• ISSN: 0196-6553; 1527-3296
• DOI: 10.1016/j.ajic.2018.04.209

•CLABSI occurs frequently among high-risk pediatric patients with intestinal failure.•An enhanced bundle for CVC care can reduce CLABSI for high-risk pediatric patients.•Through a QI initiative, PN-dependent pediatric patients have 85% less CLABSI.•Engagement of staff and leadership early in the planning is critical to success. Central line–associated bloodstream infections (CLABSIs) cause substantial morbidity and increase antimicrobial use and length of stay among hospitalized children in the United States. CLABSI occurs more frequently among high-risk pediatric patients, such as those with intestinal failure (IF) who are parenteral nutrition (PN) dependent. Following an increase in CLABSI rates, a quality improvement (QI) initiative was implemented. Using QI methodology, an enhanced central venous catheter (CVC) maintenance bundle was developed and implemented on 2 units for pediatric PN-dependent patients with IF. CLABSI rates were prospectively monitored pre- and postimplementation, and bundle element adherence was monitored. Enhanced bundle elements included chlorhexidine-impregnated patch, daily bathing, ethanol locks, 2 nurses for CVC care in a distraction-free zone, peripheral laboratory draws, bundling routine laboratory tests, and PN administration set changes every 24 hours. Adherence to enhanced bundle elements increased to >90% over 3 months. CLABSI rates averaged 1.41 per 1,000 central line days preimplementation compared with 0.40 per 1,000 device days postimplementation (P = .003), an 85% absolute reduction in CLABSI rates over 12 months. Patients with IF are at an increased risk for CLABSI. Enhanced CVC maintenance bundles that specifically target prevention practices in this population may be beneficial.