MicroRNA-Dependent Regulation of IGF1R Gene Expression in Hormone-Sensitive and Hormone-Resistant Prostate Cancer Cells

Using multiple parallel sequencing on Illumina platform, we identified eight microRNAs that showed significant opposite changes of gene expression in cells of the hormone-sensitive LNCaP prostate cancer cell line and in cells of the hormone-resistant DU-145 cell line, in comparison to the microRNA e...

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Bibliographic Details
Published in:Doklady. Biochemistry and biophysics 2018-03, Vol.479 (1), p.101-104
Main Authors: Tarasov, V. A., Tyutyakina, M. G., Makhotkin, M. A., Shin, E. F., Naboka, A. V., Mashkarina, A. N., Chebotarev, D. A., Cherkasova, E. N., Kogan, M. I., Chibichyan, M. B., Matishov, D. G.
Format: Article
Language:English
Subjects:
Biochemistry
Biological and Medical Physics
Biomedical and Life Sciences
Biophysics
Gene expression
Insulin
Insulin-like growth factor I receptors
Life Sciences
MicroRNAs
miRNA
Molecular Biology
Prostate cancer
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Summary:Using multiple parallel sequencing on Illumina platform, we identified eight microRNAs that showed significant opposite changes of gene expression in cells of the hormone-sensitive LNCaP prostate cancer cell line and in cells of the hormone-resistant DU-145 cell line, in comparison to the microRNA expression in the normal prostate tissue cells. We found that the insulin-like growth factor 1 receptor ( IGF1R ) gene is a target of five microRNAs whose expression is increased in LNCaP cells and reduced in DU-145 cells.
ISSN:1607-6729
1608-3091
DOI:10.1134/S1607672918020138