Experimental animal models of central nervous system tuberculosis: A historical review

Animal models are and will remain valuable tools in medical research because their use enables a deeper understanding of disease development, thus generating important knowledge for developing disease control strategies. Central nervous system tuberculosis (CNS TB) is the most devastating disease in...

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Bibliographic Details
Published in:Tuberculosis (Edinburgh, Scotland) Scotland), 2018-05, Vol.110, p.1-6
Main Authors: Sánchez-Garibay, Carlos, Hernández-Campos, María Elena, Tena-Suck, Martha Lilia, Salinas-Lara, Citlaltepetl
Format: Article
Language:English
Subjects:
Animal models
Animals
Antitubercular Agents - therapeutic use
Autopsies
Central nervous system
Central nervous system tuberculosis
Disease control
Disease Models, Animal
Drug development
Experimental tuberculosis
Historical account
Immunopathology
Laboratory animals
Medical research
Nervous system
Parasitic diseases
Pharmacology
Research methodology
Signs and symptoms
Tuberculosis
Tuberculosis Vaccines
Tuberculosis, Central Nervous System - etiology
Tuberculosis, Central Nervous System - immunology
Tuberculosis, Central Nervous System - therapy
Vaccination
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Summary:Animal models are and will remain valuable tools in medical research because their use enables a deeper understanding of disease development, thus generating important knowledge for developing disease control strategies. Central nervous system tuberculosis (CNS TB) is the most devastating disease in humans. Moreover, as the variability of signs and symptoms delay a timely diagnosis, patients usually arrive at the hospital suffering from late stage disease. Therefore, it is impossible to obtain fresh human tissue for research before an autopsy. Because of these reasons, studies on human CNS TB are limited to case series, pharmacological response reports, and post mortem histopathological studies. Here, we review the contribution of the different animal models to understand the immunopathology of the disease and the host-parasitic relationship, as well as in the development of new strategies of vaccination and to test new drugs for the treatment of CNS TB.
ISSN:1472-9792
1873-281X
DOI:10.1016/j.tube.2018.02.007