Evaluation of antioxidant and immune activity of Phellinus ribis glucan in mice

The potential protective effects of Phellinus ribis glucan (PRG) administration against immune injury due to free radical formation were evaluated in mice. The results showed that glucan administration significantly increased thymus and spleen indices, spleen lymphocyte proliferation and NK cells ac...

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Bibliographic Details
Published in:Food chemistry 2009-07, Vol.115 (2), p.581-584
Main Authors: Yuan, Chengfu, Huang, Xiuning, Cheng, Li, Bu, Youquan, Liu, Geli, Yi, Faping, Yang, Zhengmei, Song, Fangzhou
Format: Article
Language:English
Subjects:
animal models
Antioxidant
antioxidant activity
Biological and medical sciences
CD4-positive T-lymphocytes
CD8-positive T-lymphocytes
enzyme activity
Food industries
free radicals
fruiting bodies
Fundamental and applied biological sciences. Psychology
fungi
Glucan
glucans
glutathione peroxidase
immune response
Immune system
lymphocyte proliferation
macrophages
Mice
natural killer cells
oxidative stress
Phellinus
SOD
spleen
superoxide dismutase
thymus gland
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Summary:The potential protective effects of Phellinus ribis glucan (PRG) administration against immune injury due to free radical formation were evaluated in mice. The results showed that glucan administration significantly increased thymus and spleen indices, spleen lymphocyte proliferation and NK cells activity, as well as CD8 T cell numbers, and decreased CD4+/CD8+. In accordance with a previous study, glucan administration significantly enhanced plasma glutathione peroxidase, superoxide dismutases activity and reduced plasma thiobarbituric acid reactive species level. In conclusion, our results indicate that glucan administration improve immune function by its free radicals scavenging activity and reducing oxidative stress in mice.
ISSN:0308-8146
1873-7072
DOI:10.1016/j.foodchem.2008.12.055