New Insights into the Anion Transport Selectivity and Mechanism of Tren‐based Tris‐(thio)ureas

The anion transport properties of a series of previously reported tren‐based anionophores have been revisited using new assays designed to measure anion uniport. This study provides new insights into the transport mechanism and selectivity of this important class of transporters. Specifically, we re...

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Bibliographic Details
Published in:Chemistry : a European journal 2018-07, Vol.24 (41), p.10475-10487
Main Authors: Jowett, Laura A., Howe, Ethan N. W., Wu, Xin, Busschaert, Nathalie, Gale, Philip A.
Format: Article
Language:English
Subjects:
anion transport
Anions
bicarbonate
Bicarbonates
Chemistry
chloride
Chloride transport
nitrate
Selectivity
sulfate
Sulfates
Transport properties
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Summary:The anion transport properties of a series of previously reported tren‐based anionophores have been revisited using new assays designed to measure anion uniport. This study provides new insights into the transport mechanism and selectivity of this important class of transporters. Specifically, we report the chloride and nitrate transport selectivity of these systems and quantify sulfate transport to determine EC50 values for sulfate transport for the first time. Two new assays were developed to study bicarbonate transport allowing accurate quantification of chloride/bicarbonate exchange. Old but new: A series of previously reported tris‐(thio)ureas have been tested in a variety of anion uniport assays allowing anion selectivity to be determined.
ISSN:0947-6539
1521-3765
DOI:10.1002/chem.201801463