The association between local atherosclerosis of the prostatic artery and benign prostatic enlargement in humans: Putative mechanism of chronic ischemia for prostatic enlargement

Background To investigate the possible pathogenesis of the benign prostatic enlargement (BPE) induced by local atherosclerosis, the association between local atherosclerosis and prostatic enlargement was investigated, and molecular biological analyses were performed using human prostatectomy specime...

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Published in:The Prostate 2018-09, Vol.78 (13), p.1001-1012
Main Authors: Haga, Nobuhiro, Akaihata, Hidenori, Hata, Junya, Aikawa, Ken, Yanagida, Tomohiko, Matsuoka, Kanako, Koguchi, Tomoyuki, Hoshi, Seiji, Ogawa, Soichiro, Kataoka, Masao, Sato, Yuichi, Ishibashi, Kei, Suzuki, Osamu, Hashimoto, Yuko, Kojima, Yoshiyuki
Format: Article
Language:English
Subjects:
Arteries
Arteriosclerosis
Atherosclerosis
Benign
benign prostatic hyperplasia
Cancer surgery
Cell proliferation
Fibroblast growth factor 2
Growth factors
human
Hyperplasia
Hypoxia
Immunohistochemistry
Ischemia
lower urinary tract
lower urinary tract symptoms
Malondialdehyde
Oxidative stress
Patients
Prostate
Prostate cancer
Prostatectomy
radical prostatectomy
Robotic surgery
Transforming growth factor-b1
Urological surgery
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Summary:Background To investigate the possible pathogenesis of the benign prostatic enlargement (BPE) induced by local atherosclerosis, the association between local atherosclerosis and prostatic enlargement was investigated, and molecular biological analyses were performed using human prostatectomy specimens. Methods A total of 69 consecutive patients who underwent robot‐assisted radical prostatectomy (RARP) participated in this prospective study. To evaluate actual local atherosclerosis, prostatic arteries were removed during RARP. Microscopic assessment of local atherosclerosis was classified as one of three degrees of narrowing (minimal, moderate, and severe) according to the degree of obstruction of the inner cavity of the prostatic artery. The expressions of several mediators related to chronic ischemia and cell proliferation of the prostate were investigated by immunohistochemistry. Results The median age of the present cohort was 68 (range: 55‐75) years. Although there was no relationship between local atherosclerosis and lower urinary symptoms evaluated by questionnaires, local atherosclerosis was significantly more severe in patients who had a history of treatment for benign prostatic hyperplasia (P = 0.02). Prostate size was significantly larger in the severe local atherosclerosis group than in the minimal and moderate local atherosclerosis groups (P 
ISSN:0270-4137
1097-0045
DOI:10.1002/pros.23658