Renal stress and kidney injury biomarkers in response to endurance cycling in the heat with and without ibuprofen

Exercise, especially in the heat, can contribute to acute kidney injury, which can expedite chronic kidney disease onset. The additional stress of ibuprofen use is hypothesized to increase renal stress. To observe the effects of endurance cycling in the heat on renal function. Secondarily, we invest...

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Bibliographic Details
Published in:Journal of science and medicine in sport 2018-12, Vol.21 (12), p.1180-1184
Main Authors: McDermott, Brendon P., Smith, Cody R., Butts, Cory L., Caldwell, Aaron R., Lee, Elaine C., Vingren, Jakob L., Munoz, Colleen X., Kunces, Laura J., Williamson, Keith, Ganio, Matthew S., Armstrong, Lawrence E.
Format: Article
Language:English
Subjects:
Acute kidney injury
Acute Kidney Injury - physiopathology
Adult
Bicycling
Bicycling - physiology
Biomarkers
Biomarkers - blood
Creatinine
Creatinine - blood
Dehydration
Double-Blind Method
Female
Glomerular filtration rate
Heat
Hot Temperature - adverse effects
Humans
Hydration
Ibuprofen - therapeutic use
Kidney - drug effects
Kidney - physiopathology
Kidneys
Lipocalin-2 - blood
Male
Middle Aged
Neutrophil gelatinase-associated lipocalin
Nonsteroidal anti-inflammatory drugs
Pain
Physical Endurance
Urine
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Summary:Exercise, especially in the heat, can contribute to acute kidney injury, which can expedite chronic kidney disease onset. The additional stress of ibuprofen use is hypothesized to increase renal stress. To observe the effects of endurance cycling in the heat on renal function. Secondarily, we investigated the effect of ibuprofen ingestion on kidney stress. Randomized, placebo controlled and observational methods were utilized. Forty cyclists (52±9y, 21.7±6.5% body fat) volunteered and completed an endurance cycling event (5.7±1.2h) in the heat (33.2±5.0°C, 38.4±10.7% RH). Thirty-five participants were randomized to ingest a placebo (n=17) or 600mg ibuprofen (n=18) pre-event. A blood sample was drawn before and following the event. Serum creatinine was assessed by colorimetric assay. An ELISA was used to measure serum neutrophil gelatinase-associated lipocalin. Fractional excretion of sodium was calculated after urinary and serum electrolyte analyses. Placebo versus ibuprofen groups contributed no significant difference in any variable (p>0.05). Serum creatinine significantly increased from pre- (0.52±0.14mg/dL) to post-event (0.88±0.21mg/dL; p
ISSN:1440-2440
1878-1861
DOI:10.1016/j.jsams.2018.05.003