Mechanisms of cell regulation – proteolysis, the big surprise

Precise regulation of cellular processes is essential for life. Regarding proteins, many regulatory mechanisms were explored over the years, such as posttranslational modifications (e.g., phosphorylation), enzyme activation or inhibition by small molecules, and modulation of protein–protein interact...

Full description

Saved in:
Bibliographic Details
Published in:FEBS letters 2018-08, Vol.592 (15), p.2515-2524
Main Authors: Wolf, Dieter H., Menssen, Ruth
Format: Article
Language:English
Subjects:
autophagy
lysosome/vacuole
proteolysis
ubiquitin–proteasome system
yeast
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c3859-765d40cc82bcc35afe4d382d56047fa87bc897f3b54cacbdbb1467e414391d8d3
cites cdi_FETCH-LOGICAL-c3859-765d40cc82bcc35afe4d382d56047fa87bc897f3b54cacbdbb1467e414391d8d3
container_end_page 2524
container_issue 15
container_start_page 2515
container_title FEBS letters
container_volume 592
creator Wolf, Dieter H.
Menssen, Ruth
description Precise regulation of cellular processes is essential for life. Regarding proteins, many regulatory mechanisms were explored over the years, such as posttranslational modifications (e.g., phosphorylation), enzyme activation or inhibition by small molecules, and modulation of protein–protein interactions. Complete removal of a protein via proteolysis as a regulatory mechanism, however, was denied for a long time, mainly due to economical considerations. Scientists could not believe that a protein which is synthesized at the expense of a lot of energy could be destroyed again. Here, we discuss the landmark discoveries and the use of yeast as a eukaryotic model organism that finally paved the way for our current understanding of proteolysis as an essential regulatory principle in the cell.
doi_str_mv 10.1002/1873-3468.13109
format article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2043168446</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2043168446</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3859-765d40cc82bcc35afe4d382d56047fa87bc897f3b54cacbdbb1467e414391d8d3</originalsourceid><addsrcrecordid>eNqFkL1OwzAURi0EoqUwsyGPDKS1Yye2JwRVC0hFLDBb_ksblDTFTlR14x14Q56EhJSuTFf36txPnw4AlxiNMULxBHNGIkJTPsYEI3EEhofLMRgihGmUMEEG4CyEd9TuHItTMIgFEwizZAhun51ZqXUeygCrDBpXFNC7ZVOoOq_W8PvzC258Vbuq2IU83MB65aDOlzA0fuPz4M7BSaaK4C72cwTe5rPX6WO0eHl4mt4tIkN4IiKWJpYiY3isjSGJyhy1hMc2SRFlmeJMGy5YRnRCjTLaao1pyhzFlAhsuSUjcN3ntm0-GhdqWeaha6vWrmqCjBElOOWUpi066VHjqxC8y2TbtFR-JzGSnTXZOZKdI_lrrf242oc3unT2wP9paoG0B7Z54Xb_5cn57D7uk38AJTJ3Vg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2043168446</pqid></control><display><type>article</type><title>Mechanisms of cell regulation – proteolysis, the big surprise</title><source>Wiley-Blackwell Read &amp; Publish Collection</source><creator>Wolf, Dieter H. ; Menssen, Ruth</creator><creatorcontrib>Wolf, Dieter H. ; Menssen, Ruth</creatorcontrib><description>Precise regulation of cellular processes is essential for life. Regarding proteins, many regulatory mechanisms were explored over the years, such as posttranslational modifications (e.g., phosphorylation), enzyme activation or inhibition by small molecules, and modulation of protein–protein interactions. Complete removal of a protein via proteolysis as a regulatory mechanism, however, was denied for a long time, mainly due to economical considerations. Scientists could not believe that a protein which is synthesized at the expense of a lot of energy could be destroyed again. Here, we discuss the landmark discoveries and the use of yeast as a eukaryotic model organism that finally paved the way for our current understanding of proteolysis as an essential regulatory principle in the cell.</description><identifier>ISSN: 0014-5793</identifier><identifier>EISSN: 1873-3468</identifier><identifier>DOI: 10.1002/1873-3468.13109</identifier><identifier>PMID: 29790175</identifier><language>eng</language><publisher>England</publisher><subject>autophagy ; lysosome/vacuole ; proteolysis ; ubiquitin–proteasome system ; yeast</subject><ispartof>FEBS letters, 2018-08, Vol.592 (15), p.2515-2524</ispartof><rights>2018 Federation of European Biochemical Societies</rights><rights>2018 Federation of European Biochemical Societies.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3859-765d40cc82bcc35afe4d382d56047fa87bc897f3b54cacbdbb1467e414391d8d3</citedby><cites>FETCH-LOGICAL-c3859-765d40cc82bcc35afe4d382d56047fa87bc897f3b54cacbdbb1467e414391d8d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27900,27901</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29790175$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wolf, Dieter H.</creatorcontrib><creatorcontrib>Menssen, Ruth</creatorcontrib><title>Mechanisms of cell regulation – proteolysis, the big surprise</title><title>FEBS letters</title><addtitle>FEBS Lett</addtitle><description>Precise regulation of cellular processes is essential for life. Regarding proteins, many regulatory mechanisms were explored over the years, such as posttranslational modifications (e.g., phosphorylation), enzyme activation or inhibition by small molecules, and modulation of protein–protein interactions. Complete removal of a protein via proteolysis as a regulatory mechanism, however, was denied for a long time, mainly due to economical considerations. Scientists could not believe that a protein which is synthesized at the expense of a lot of energy could be destroyed again. Here, we discuss the landmark discoveries and the use of yeast as a eukaryotic model organism that finally paved the way for our current understanding of proteolysis as an essential regulatory principle in the cell.</description><subject>autophagy</subject><subject>lysosome/vacuole</subject><subject>proteolysis</subject><subject>ubiquitin–proteasome system</subject><subject>yeast</subject><issn>0014-5793</issn><issn>1873-3468</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNqFkL1OwzAURi0EoqUwsyGPDKS1Yye2JwRVC0hFLDBb_ksblDTFTlR14x14Q56EhJSuTFf36txPnw4AlxiNMULxBHNGIkJTPsYEI3EEhofLMRgihGmUMEEG4CyEd9TuHItTMIgFEwizZAhun51ZqXUeygCrDBpXFNC7ZVOoOq_W8PvzC258Vbuq2IU83MB65aDOlzA0fuPz4M7BSaaK4C72cwTe5rPX6WO0eHl4mt4tIkN4IiKWJpYiY3isjSGJyhy1hMc2SRFlmeJMGy5YRnRCjTLaao1pyhzFlAhsuSUjcN3ntm0-GhdqWeaha6vWrmqCjBElOOWUpi066VHjqxC8y2TbtFR-JzGSnTXZOZKdI_lrrf242oc3unT2wP9paoG0B7Z54Xb_5cn57D7uk38AJTJ3Vg</recordid><startdate>201808</startdate><enddate>201808</enddate><creator>Wolf, Dieter H.</creator><creator>Menssen, Ruth</creator><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201808</creationdate><title>Mechanisms of cell regulation – proteolysis, the big surprise</title><author>Wolf, Dieter H. ; Menssen, Ruth</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3859-765d40cc82bcc35afe4d382d56047fa87bc897f3b54cacbdbb1467e414391d8d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>autophagy</topic><topic>lysosome/vacuole</topic><topic>proteolysis</topic><topic>ubiquitin–proteasome system</topic><topic>yeast</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wolf, Dieter H.</creatorcontrib><creatorcontrib>Menssen, Ruth</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>FEBS letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wolf, Dieter H.</au><au>Menssen, Ruth</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mechanisms of cell regulation – proteolysis, the big surprise</atitle><jtitle>FEBS letters</jtitle><addtitle>FEBS Lett</addtitle><date>2018-08</date><risdate>2018</risdate><volume>592</volume><issue>15</issue><spage>2515</spage><epage>2524</epage><pages>2515-2524</pages><issn>0014-5793</issn><eissn>1873-3468</eissn><abstract>Precise regulation of cellular processes is essential for life. Regarding proteins, many regulatory mechanisms were explored over the years, such as posttranslational modifications (e.g., phosphorylation), enzyme activation or inhibition by small molecules, and modulation of protein–protein interactions. Complete removal of a protein via proteolysis as a regulatory mechanism, however, was denied for a long time, mainly due to economical considerations. Scientists could not believe that a protein which is synthesized at the expense of a lot of energy could be destroyed again. Here, we discuss the landmark discoveries and the use of yeast as a eukaryotic model organism that finally paved the way for our current understanding of proteolysis as an essential regulatory principle in the cell.</abstract><cop>England</cop><pmid>29790175</pmid><doi>10.1002/1873-3468.13109</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0014-5793
ispartof FEBS letters, 2018-08, Vol.592 (15), p.2515-2524
issn 0014-5793
1873-3468
language eng
recordid cdi_proquest_miscellaneous_2043168446
source Wiley-Blackwell Read & Publish Collection
subjects autophagy
lysosome/vacuole
proteolysis
ubiquitin–proteasome system
yeast
title Mechanisms of cell regulation – proteolysis, the big surprise
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-25T11%3A06%3A40IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Mechanisms%20of%20cell%20regulation%20%E2%80%93%20proteolysis,%20the%20big%20surprise&rft.jtitle=FEBS%20letters&rft.au=Wolf,%20Dieter%20H.&rft.date=2018-08&rft.volume=592&rft.issue=15&rft.spage=2515&rft.epage=2524&rft.pages=2515-2524&rft.issn=0014-5793&rft.eissn=1873-3468&rft_id=info:doi/10.1002/1873-3468.13109&rft_dat=%3Cproquest_cross%3E2043168446%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c3859-765d40cc82bcc35afe4d382d56047fa87bc897f3b54cacbdbb1467e414391d8d3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2043168446&rft_id=info:pmid/29790175&rfr_iscdi=true