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Systematic evaluation of clinical practice guidelines for pharmacogenomics
To systematically assess methodological quality of pharmacogenomics clinical practice guidelines. Guidelines published through 2017 were reviewed by at least three independent reviewers using the AGREE II instrument, which consists of 23 items grouped into 6 domains and 2 items representing an overa...
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Published in: | Pharmacogenomics 2018-06, Vol.19 (8), p.693-700 |
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container_title | Pharmacogenomics |
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creator | Beckett, Robert D Kisor, David F Smith, Thomas Vonada, Brooke |
description | To systematically assess methodological quality of pharmacogenomics clinical practice guidelines.
Guidelines published through 2017 were reviewed by at least three independent reviewers using the AGREE II instrument, which consists of 23 items grouped into 6 domains and 2 items representing an overall assessment. Items were assessed on a 7-point rating scale, and aggregate quality scores were calculated.
Thirty-one articles were included. All guidelines were published as peer-reviewed articles and 90% (n = 28) were endorsed by professional organizations. Mean AGREE II domain scores (maximum score 100%) ranged from 46.6 ± 11.5% ('applicability') to 78.9 ± 11.4% ('Clarity of Presentation'). Median overall quality score was 72.2% (IQR: 61.1-77.8%).
Quality of pharmacogenomics guidelines was generally high, but variable, for most AGREE II domains. |
doi_str_mv | 10.2217/pgs-2018-0024 |
format | article |
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Guidelines published through 2017 were reviewed by at least three independent reviewers using the AGREE II instrument, which consists of 23 items grouped into 6 domains and 2 items representing an overall assessment. Items were assessed on a 7-point rating scale, and aggregate quality scores were calculated.
Thirty-one articles were included. All guidelines were published as peer-reviewed articles and 90% (n = 28) were endorsed by professional organizations. Mean AGREE II domain scores (maximum score 100%) ranged from 46.6 ± 11.5% ('applicability') to 78.9 ± 11.4% ('Clarity of Presentation'). Median overall quality score was 72.2% (IQR: 61.1-77.8%).
Quality of pharmacogenomics guidelines was generally high, but variable, for most AGREE II domains.</description><identifier>ISSN: 1462-2416</identifier><identifier>EISSN: 1744-8042</identifier><identifier>DOI: 10.2217/pgs-2018-0024</identifier><identifier>PMID: 29790417</identifier><language>eng</language><publisher>England: Future Medicine Ltd</publisher><subject>AGREE II ; Chemotherapy ; Clinical medicine ; Clinical practice guidelines ; Collaboration ; Consortia ; Decision making ; Drug dosages ; Evidence-Based Medicine - standards ; evidence-based practice ; Fractures ; Genomes ; Health care ; Humans ; Oncology ; Pharmacists ; Pharmacogenetics - standards ; Pharmacogenomics ; Quality ; Reviews</subject><ispartof>Pharmacogenomics, 2018-06, Vol.19 (8), p.693-700</ispartof><rights>2018 Future Medicine Ltd</rights><rights>Copyright Future Medicine Ltd Jun 2018</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c371t-456d4f82b0f217cb8e6a4586c01515aefb1940899d176f516fb58b2aea7800aa3</citedby><cites>FETCH-LOGICAL-c371t-456d4f82b0f217cb8e6a4586c01515aefb1940899d176f516fb58b2aea7800aa3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29790417$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Beckett, Robert D</creatorcontrib><creatorcontrib>Kisor, David F</creatorcontrib><creatorcontrib>Smith, Thomas</creatorcontrib><creatorcontrib>Vonada, Brooke</creatorcontrib><title>Systematic evaluation of clinical practice guidelines for pharmacogenomics</title><title>Pharmacogenomics</title><addtitle>Pharmacogenomics</addtitle><description>To systematically assess methodological quality of pharmacogenomics clinical practice guidelines.
Guidelines published through 2017 were reviewed by at least three independent reviewers using the AGREE II instrument, which consists of 23 items grouped into 6 domains and 2 items representing an overall assessment. Items were assessed on a 7-point rating scale, and aggregate quality scores were calculated.
Thirty-one articles were included. All guidelines were published as peer-reviewed articles and 90% (n = 28) were endorsed by professional organizations. Mean AGREE II domain scores (maximum score 100%) ranged from 46.6 ± 11.5% ('applicability') to 78.9 ± 11.4% ('Clarity of Presentation'). Median overall quality score was 72.2% (IQR: 61.1-77.8%).
Quality of pharmacogenomics guidelines was generally high, but variable, for most AGREE II domains.</description><subject>AGREE II</subject><subject>Chemotherapy</subject><subject>Clinical medicine</subject><subject>Clinical practice guidelines</subject><subject>Collaboration</subject><subject>Consortia</subject><subject>Decision making</subject><subject>Drug dosages</subject><subject>Evidence-Based Medicine - standards</subject><subject>evidence-based practice</subject><subject>Fractures</subject><subject>Genomes</subject><subject>Health care</subject><subject>Humans</subject><subject>Oncology</subject><subject>Pharmacists</subject><subject>Pharmacogenetics - standards</subject><subject>Pharmacogenomics</subject><subject>Quality</subject><subject>Reviews</subject><issn>1462-2416</issn><issn>1744-8042</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp1kE1LxDAQhoMo7rp69CoFL16qSZom7VEWP1nwoJ5Dmk7WLG1Tk1bYf2-Wrh4ET5nMPPMyPAidE3xNKRE3_TqkFJMixZiyAzQngrG0wIwexppxmlJG-AydhLCJBOEMH6MZLUWJGRFz9Py6DQO0arA6gS_VjLFyXeJMohvbWa2apPdKxzEk69HWELsQEuN80n8o3yrt1tC51upwio6MagKc7d8Fer-_e1s-pquXh6fl7SrVmSBDynJeM1PQCpt4v64K4IrlBdeY5CRXYCpSMlyUZU0ENznhpsqLiipQosBYqWyBrqbc3rvPEcIgWxs0NI3qwI1BUswyImie04he_kE3bvRdvE7SjPIyE1FapNKJ0t6F4MHI3ttW-a0kWO4kyyhZ7iRLPPEX-9SxaqH-pX-sRqCcADMOo4egLXQa5PSLG1ZHif-EfwMPt4r1</recordid><startdate>20180601</startdate><enddate>20180601</enddate><creator>Beckett, Robert D</creator><creator>Kisor, David F</creator><creator>Smith, Thomas</creator><creator>Vonada, Brooke</creator><general>Future Medicine Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>EHMNL</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20180601</creationdate><title>Systematic evaluation of clinical practice guidelines for pharmacogenomics</title><author>Beckett, Robert D ; Kisor, David F ; Smith, Thomas ; Vonada, Brooke</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c371t-456d4f82b0f217cb8e6a4586c01515aefb1940899d176f516fb58b2aea7800aa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>AGREE II</topic><topic>Chemotherapy</topic><topic>Clinical medicine</topic><topic>Clinical practice guidelines</topic><topic>Collaboration</topic><topic>Consortia</topic><topic>Decision making</topic><topic>Drug dosages</topic><topic>Evidence-Based Medicine - standards</topic><topic>evidence-based practice</topic><topic>Fractures</topic><topic>Genomes</topic><topic>Health care</topic><topic>Humans</topic><topic>Oncology</topic><topic>Pharmacists</topic><topic>Pharmacogenetics - standards</topic><topic>Pharmacogenomics</topic><topic>Quality</topic><topic>Reviews</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Beckett, Robert D</creatorcontrib><creatorcontrib>Kisor, David F</creatorcontrib><creatorcontrib>Smith, Thomas</creatorcontrib><creatorcontrib>Vonada, Brooke</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>ProQuest UK & Ireland Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection (Proquest) (PQ_SDU_P3)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Biological Science Journals</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Pharmacogenomics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Beckett, Robert D</au><au>Kisor, David F</au><au>Smith, Thomas</au><au>Vonada, Brooke</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Systematic evaluation of clinical practice guidelines for pharmacogenomics</atitle><jtitle>Pharmacogenomics</jtitle><addtitle>Pharmacogenomics</addtitle><date>2018-06-01</date><risdate>2018</risdate><volume>19</volume><issue>8</issue><spage>693</spage><epage>700</epage><pages>693-700</pages><issn>1462-2416</issn><eissn>1744-8042</eissn><abstract>To systematically assess methodological quality of pharmacogenomics clinical practice guidelines.
Guidelines published through 2017 were reviewed by at least three independent reviewers using the AGREE II instrument, which consists of 23 items grouped into 6 domains and 2 items representing an overall assessment. Items were assessed on a 7-point rating scale, and aggregate quality scores were calculated.
Thirty-one articles were included. All guidelines were published as peer-reviewed articles and 90% (n = 28) were endorsed by professional organizations. Mean AGREE II domain scores (maximum score 100%) ranged from 46.6 ± 11.5% ('applicability') to 78.9 ± 11.4% ('Clarity of Presentation'). Median overall quality score was 72.2% (IQR: 61.1-77.8%).
Quality of pharmacogenomics guidelines was generally high, but variable, for most AGREE II domains.</abstract><cop>England</cop><pub>Future Medicine Ltd</pub><pmid>29790417</pmid><doi>10.2217/pgs-2018-0024</doi><tpages>8</tpages></addata></record> |
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subjects | AGREE II Chemotherapy Clinical medicine Clinical practice guidelines Collaboration Consortia Decision making Drug dosages Evidence-Based Medicine - standards evidence-based practice Fractures Genomes Health care Humans Oncology Pharmacists Pharmacogenetics - standards Pharmacogenomics Quality Reviews |
title | Systematic evaluation of clinical practice guidelines for pharmacogenomics |
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