Base-Mediated Intramolecular Decarboxylative Synthesis of Alkylamines from Alkanoyloxycarbamates

A general and effective method for the synthesis of alkylamine via intramolecular decarboxylation of alkanoyloxycarbamates is described. The alkanoyloxycarbamates are readily prepared with alkyl carboxylic acids and hydroxylamine. The reaction shows a broad range of substrates (primary and secondary...

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Published in:Journal of organic chemistry 2018-08, Vol.83 (15), p.8233-8240
Main Authors: Li, Peihe, Ma, Nuannuan, Wang, Zheng, Dai, Qipu, Hu, Changwen
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Language:English
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container_issue 15
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container_title Journal of organic chemistry
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creator Li, Peihe
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description A general and effective method for the synthesis of alkylamine via intramolecular decarboxylation of alkanoyloxycarbamates is described. The alkanoyloxycarbamates are readily prepared with alkyl carboxylic acids and hydroxylamine. The reaction shows a broad range of substrates (primary and secondary alkyl) with functional tolerance, and the corresponding products were obtained in good yields under mild conditions.
doi_str_mv 10.1021/acs.joc.8b00970
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title Base-Mediated Intramolecular Decarboxylative Synthesis of Alkylamines from Alkanoyloxycarbamates
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