Oral hydroxysafflor yellow A reduces obesity in mice by modulating the gut microbiota and serum metabolism

[Display omitted] Given the high and increasing prevalence of obesity, the safe and effective treatment of obesity would be beneficial. Here, we examined whether oral hydroxysafflor yellow A (HSYA), an active compound from the dried florets of Carthamus tinctorius L., can reduce high-fat (HF) diet-i...

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Bibliographic Details
Published in:Pharmacological research 2018-08, Vol.134, p.40-50
Main Authors: Liu, Juan, Yue, Shijun, Yang, Zhirui, Feng, Wuwen, Meng, Xintong, Wang, Aiting, Peng, Cheng, Wang, Changyun, Yan, Dan
Format: Article
Language:English
Subjects:
Adiposity - drug effects
Administration, Oral
Akkermansia
Animals
Anti-Obesity Agents - administration & dosage
Bacteria - drug effects
Bacteria - growth & development
Bacteria - metabolism
Biomarkers - blood
Blood Glucose - metabolism
Chalcone - administration & dosage
Chalcone - analogs & derivatives
Diet, High-Fat
Disease Models, Animal
Energy Metabolism - drug effects
Fatty Acids, Volatile - blood
Gastrointestinal Microbiome - drug effects
Hydroxysafflor yellow A
Insulin - blood
Insulin Resistance
Intestines - drug effects
Intestines - microbiology
Lysophosphatidylcholine
Male
Metabolomics - methods
Mice, Inbred C57BL
Obesity
Obesity - blood
Obesity - microbiology
Obesity - physiopathology
Obesity - prevention & control
Quinones - administration & dosage
Romboutsia
Weight Loss - drug effects
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Summary:[Display omitted] Given the high and increasing prevalence of obesity, the safe and effective treatment of obesity would be beneficial. Here, we examined whether oral hydroxysafflor yellow A (HSYA), an active compound from the dried florets of Carthamus tinctorius L., can reduce high-fat (HF) diet-induced obesity in C57BL/6 J mice. Our results showed that the average body weight of HF group treated by HSYA was significantly lower than that of the HF group (P 
ISSN:1043-6618
1096-1186
DOI:10.1016/j.phrs.2018.05.012