Pericytes in the Premetastatic Niche

The premetastatic niche formed by primary tumor-derived molecules contributes to fixation of cancer metastasis. The design of efficient therapies is limited by the current lack of knowledge about the details of cellular and molecular mechanisms involved in the premetastatic niche formation. Recently...

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Bibliographic Details
Published in:Cancer research (Chicago, Ill.) Ill.), 2018-06, Vol.78 (11), p.2779-2786
Main Authors: Paiva, Ana E, Lousado, Luiza, Guerra, Daniel A P, Azevedo, Patrick O, Sena, Isadora F G, Andreotti, Julia P, Santos, Gabryella S P, Gonçalves, Ricardo, Mintz, Akiva, Birbrair, Alexander
Format: Article
Language:English
Subjects:
Animals
Cancer
Clonal deletion
Humans
Inactivation
KLF4 protein
Kruppel-Like Factor 4
Kruppel-Like Transcription Factors - genetics
Lung - pathology
Lung Neoplasms - genetics
Lung Neoplasms - pathology
Lungs
Metastases
Metastasis
Molecular chains
Molecular modelling
Neoplasm Metastasis - genetics
Neoplasm Metastasis - pathology
Pericytes
Pericytes - pathology
Tropism
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Summary:The premetastatic niche formed by primary tumor-derived molecules contributes to fixation of cancer metastasis. The design of efficient therapies is limited by the current lack of knowledge about the details of cellular and molecular mechanisms involved in the premetastatic niche formation. Recently, the role of pericytes in the premetastatic niche formation and lung metastatic tropism was explored by using state-of-the-art techniques, including lineage-tracing and mice with pericyte-specific KLF4 deletion. Strikingly, genetic inactivation of KLF4 in pericytes inhibits pulmonary pericyte expansion and decreases metastasis in the lung. Here, we summarize and evaluate recent advances in the understanding of pericyte contribution to premetastatic niche formation. .
ISSN:0008-5472
1538-7445
1538-7445
DOI:10.1158/0008-5472.CAN-17-3883