Effect of Interleukin‐10 on Tissue Damage Caused by Organophosphate Poisoning

:  Organophosphate poisoning is a common cause of severe morbidity and mortality among patients admitted to emergency departments. Tissue damages as a consequence of organophosphate poisoning are frequently reported, but preventing this potentially severe complication has not been the subject of muc...

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Published in:Basic & clinical pharmacology & toxicology 2007-05, Vol.100 (5), p.323-327
Main Authors: Yurumez, Yusuf, Ikizceli, Ibrahim, Sozuer, Erdogan Mutevelli, Soyuer, Isın, Yavuz, Yucel, Avsarogullari, Levent, Durukan, Polat
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Chemical and Drug Induced Liver Injury - pathology
Chemical and Drug Induced Liver Injury - prevention & control
Cholinesterase Inhibitors - poisoning
Drug Antagonism
Drug Therapy, Combination
Female
Fenthion - poisoning
Injections, Intraperitoneal
Interleukin-10 - pharmacology
Kidney Diseases - chemically induced
Kidney Diseases - pathology
Kidney Diseases - prevention & control
Lung Diseases - chemically induced
Lung Diseases - pathology
Lung Diseases - prevention & control
Medical sciences
Pharmacology. Drug treatments
Rats
Rats, Wistar
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Summary::  Organophosphate poisoning is a common cause of severe morbidity and mortality among patients admitted to emergency departments. Tissue damages as a consequence of organophosphate poisoning are frequently reported, but preventing this potentially severe complication has not been the subject of much research. We tested whether interleukin‐10, a cytoprotective agent, could prevent or diminish pathological signs of tissue damages caused by organophosphate poisoning. Thirty rats were divided into three equal groups (n = 10). Group 1 (sham) did not receive any agent during the experiment. Group 2 (control) received 0.8 g/kg of fenthion intraperitoneally, followed by 6 ml/kg of intraperitoneal normal saline 30 min. and 3 hr later. Group 3 (treatment) received 0.8 g/kg of fenthion intraperitoneally, followed by 2 µg/kg of interleukin‐10 intraperitoneally 30 min. and 3 hr later. All rats were killed under anaesthesia after 6 hr and tissue samples were obtained from liver, kidneys and lungs. Even organophosphate poisonings do not cause significant clinical problems; several degrees of damages could be observed in liver, kidneys and lungs. These damages could be reduced by interleukin‐10 treatment.
ISSN:1742-7835
1742-7843
DOI:10.1111/j.1742-7843.2007.00049.x