Single-Nucleotide Polymorphisms in IL23R-IL12RB2 (rs1495965) Are Highly Prevalent in Patients with Behcet's Uveitis and Vary Between Populations

Purpose: To test the frequency of single-nucleotide polymorphisms in the IL-10, IL23R-IL12RB2 genes in patients with Behcet's uveitis. Methods: Blood samples were collected from 89 Israeli and Turkish patients, and from healthy control subjects of different origins. Genomic DNA was extracted fr...

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Published in:Ocular immunology and inflammation 2019-07, Vol.27 (5), p.766-773
Main Authors: Kramer, Michal, Hasanreisoglu, Murat, Weiss, Shirel, Kumova, Deniz, Schaap-Fogler, Michal, Guntekin-Ergun, Sezen, Ozdek, Sengul, Gurelik, Gokhan, Ergün, Mehmet Ali, Goldenberg-Cohen, Nitza, Cohen, Yoram
Format: Article
Language:English
Subjects:
Adult
Behcet Syndrome - complications
Behcet Syndrome - epidemiology
Behcet Syndrome - genetics
Behcet's disease
Case-Control Studies
Female
Gene Frequency
Genetic Predisposition to Disease
Humans
IL-10
IL23R-IL12RB2
Israel - epidemiology
Male
Middle Aged
Polymorphism, Single Nucleotide
Receptors, Interleukin - genetics
Receptors, Interleukin-12 - genetics
SNP
Turkey - epidemiology
uveitis
Uveitis - epidemiology
Uveitis - etiology
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Summary:Purpose: To test the frequency of single-nucleotide polymorphisms in the IL-10, IL23R-IL12RB2 genes in patients with Behcet's uveitis. Methods: Blood samples were collected from 89 Israeli and Turkish patients, and from healthy control subjects of different origins. Genomic DNA was extracted from peripheral blood leukocytes and genotyped. Results: The risk allele, A, in rs1800871, of IL-10 gene was highly prevalent in Behcet's uveitis and healthy control samples alike; highest among the Turkish groups. Prevalence of G allele, in rs1495965, in the IL23R-IL12RB2 gene was high in Behcet's uveitis patients, and among healthy Turkish and Israelis of Middle Eastern origin, while lower among the other Israeli control group (77.9%, 78.9%, 27.8%, respectively, P 
ISSN:0927-3948
1744-5078
DOI:10.1080/09273948.2018.1467463