Nickel(II)-Catalyzed [8 + 3]-Cycloaddition of 2‑Aryl‑N‑tosylaziridines with Tropone

The Ni-catalyzed [8 + 3]-cycloaddition of tropone with 2-aryl-N-tosylaziridines proceeded smoothly under mild reaction conditions, affording various 4-tosyl-2,3,4,4a-tetrahydrocyclohepta­[b]­[1,4]­oxazine derivatives in moderate to excellent yields.

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Bibliographic Details
Published in:Organic letters 2018-06, Vol.20 (12), p.3570-3573
Main Authors: Liu, Honglei, Jia, Hao, Shi, Wangyu, Wang, Chang, Zhang, Cheng, Guo, Hongchao
Format: Article
Language:English
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Summary:The Ni-catalyzed [8 + 3]-cycloaddition of tropone with 2-aryl-N-tosylaziridines proceeded smoothly under mild reaction conditions, affording various 4-tosyl-2,3,4,4a-tetrahydrocyclohepta­[b]­[1,4]­oxazine derivatives in moderate to excellent yields.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.8b01354