Association between a pro-inflammatory genetic profile and the risk of chronic atrophic gastritis among older adults from Germany

Abstract Background Pro-inflammatory polymorphisms have been suggested to explain part of the individual diversity in susceptibility to gastric carcinogenesis. We aimed to assess their impact on the risk of chronic atrophic gastritis (CAG) in a population-based study. Methods Among 9953 older adults...

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Published in:European journal of cancer (1990) 2009-02, Vol.45 (3), p.428-434
Main Authors: Gao, Lei, Weck, Melanie N, Nieters, Alexandra, Brenner, Hermann
Format: Article
Language:English
Subjects:
Aged
Biological and medical sciences
Chronic atrophic gastritis
Cytokines - genetics
Female
Gastritis, Atrophic - epidemiology
Gastritis, Atrophic - genetics
Gene Expression Profiling
Genetic Predisposition to Disease - epidemiology
Genetic Predisposition to Disease - genetics
Germany - epidemiology
Hematology, Oncology and Palliative Medicine
Humans
Interleukin-10
Male
Medical sciences
Middle Aged
Odds Ratio
Pharmacology. Drug treatments
Polymorphism
Polymorphism, Single Nucleotide - genetics
Pro-inflammatory
Risk Factors
Stomach Neoplasms - epidemiology
Stomach Neoplasms - genetics
Susceptibility
Tumors
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container_start_page 428
container_title European journal of cancer (1990)
container_volume 45
creator Gao, Lei
Weck, Melanie N
Nieters, Alexandra
Brenner, Hermann
description Abstract Background Pro-inflammatory polymorphisms have been suggested to explain part of the individual diversity in susceptibility to gastric carcinogenesis. We aimed to assess their impact on the risk of chronic atrophic gastritis (CAG) in a population-based study. Methods Among 9953 older adults from Saarland/Germany, eight single nucleotide polymorphisms (SNPs) were assessed for 534 cases with serologically defined CAG and 534 age- and sex-matched controls at baseline examination. Results Of the 8 SNPs, only IL10 T-819C showed a borderline significant association with CAG risk (odds ratio for CC versus TT: 1.67 (95% confidence interval: 1.01–2.76)). No significant differences were observed for the distribution of inferred haplotypes between cases and controls. However, joint evaluation of several cytokine variants suggested an increased risk of CAG among individuals carrying several pro-inflammatory genotypes. Conclusions Our findings suggest that a pro-inflammatory genetic profile may contribute to inter-individual variation in gastric cancer risk by increasing the susceptibility to the development of CAG.
doi_str_mv 10.1016/j.ejca.2008.09.019
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We aimed to assess their impact on the risk of chronic atrophic gastritis (CAG) in a population-based study. Methods Among 9953 older adults from Saarland/Germany, eight single nucleotide polymorphisms (SNPs) were assessed for 534 cases with serologically defined CAG and 534 age- and sex-matched controls at baseline examination. Results Of the 8 SNPs, only IL10 T-819C showed a borderline significant association with CAG risk (odds ratio for CC versus TT: 1.67 (95% confidence interval: 1.01–2.76)). No significant differences were observed for the distribution of inferred haplotypes between cases and controls. However, joint evaluation of several cytokine variants suggested an increased risk of CAG among individuals carrying several pro-inflammatory genotypes. Conclusions Our findings suggest that a pro-inflammatory genetic profile may contribute to inter-individual variation in gastric cancer risk by increasing the susceptibility to the development of CAG.</description><identifier>ISSN: 0959-8049</identifier><identifier>EISSN: 1879-0852</identifier><identifier>DOI: 10.1016/j.ejca.2008.09.019</identifier><identifier>PMID: 19013788</identifier><language>eng</language><publisher>Kidlington: Elsevier Ltd</publisher><subject>Aged ; Biological and medical sciences ; Chronic atrophic gastritis ; Cytokines - genetics ; Female ; Gastritis, Atrophic - epidemiology ; Gastritis, Atrophic - genetics ; Gene Expression Profiling ; Genetic Predisposition to Disease - epidemiology ; Genetic Predisposition to Disease - genetics ; Germany - epidemiology ; Hematology, Oncology and Palliative Medicine ; Humans ; Interleukin-10 ; Male ; Medical sciences ; Middle Aged ; Odds Ratio ; Pharmacology. 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We aimed to assess their impact on the risk of chronic atrophic gastritis (CAG) in a population-based study. Methods Among 9953 older adults from Saarland/Germany, eight single nucleotide polymorphisms (SNPs) were assessed for 534 cases with serologically defined CAG and 534 age- and sex-matched controls at baseline examination. Results Of the 8 SNPs, only IL10 T-819C showed a borderline significant association with CAG risk (odds ratio for CC versus TT: 1.67 (95% confidence interval: 1.01–2.76)). No significant differences were observed for the distribution of inferred haplotypes between cases and controls. However, joint evaluation of several cytokine variants suggested an increased risk of CAG among individuals carrying several pro-inflammatory genotypes. Conclusions Our findings suggest that a pro-inflammatory genetic profile may contribute to inter-individual variation in gastric cancer risk by increasing the susceptibility to the development of CAG.</description><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Chronic atrophic gastritis</subject><subject>Cytokines - genetics</subject><subject>Female</subject><subject>Gastritis, Atrophic - epidemiology</subject><subject>Gastritis, Atrophic - genetics</subject><subject>Gene Expression Profiling</subject><subject>Genetic Predisposition to Disease - epidemiology</subject><subject>Genetic Predisposition to Disease - genetics</subject><subject>Germany - epidemiology</subject><subject>Hematology, Oncology and Palliative Medicine</subject><subject>Humans</subject><subject>Interleukin-10</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Odds Ratio</subject><subject>Pharmacology. 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identifier ISSN: 0959-8049
ispartof European journal of cancer (1990), 2009-02, Vol.45 (3), p.428-434
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1879-0852
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source ScienceDirect Freedom Collection 2022-2024
subjects Aged
Biological and medical sciences
Chronic atrophic gastritis
Cytokines - genetics
Female
Gastritis, Atrophic - epidemiology
Gastritis, Atrophic - genetics
Gene Expression Profiling
Genetic Predisposition to Disease - epidemiology
Genetic Predisposition to Disease - genetics
Germany - epidemiology
Hematology, Oncology and Palliative Medicine
Humans
Interleukin-10
Male
Medical sciences
Middle Aged
Odds Ratio
Pharmacology. Drug treatments
Polymorphism
Polymorphism, Single Nucleotide - genetics
Pro-inflammatory
Risk Factors
Stomach Neoplasms - epidemiology
Stomach Neoplasms - genetics
Susceptibility
Tumors
title Association between a pro-inflammatory genetic profile and the risk of chronic atrophic gastritis among older adults from Germany
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