Environmental modulation of anxiety-related neuronal activity and behaviors

Enkephalin-deficient knockout mice, a genetic model of enhanced anxiety responses, and wild-type controls were housed in two separate facilities on the same campus using different caging systems. Stress reactivity was evaluated in these animals using a zero-maze test followed by c-Fos expression ana...

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Bibliographic Details
Published in:Behavioural brain research 2008-01, Vol.186 (2), p.289-292
Main Authors: Bilkei-Gorzó, András, Otto, Martin, Zimmer, Andreas
Format: Article
Language:English
Subjects:
Amphetamine
Amphetamine - adverse effects
Analysis of Variance
Animals
Anxiety - genetics
Anxiety - pathology
Anxiety - physiopathology
Anxiety behavior
Behavior, Animal - physiology
Behavioral psychophysiology
Biological and medical sciences
c-fos
Central Nervous System Stimulants - adverse effects
Disease Models, Animal
Enkephalins - deficiency
Environment
Environmental effect
Fundamental and applied biological sciences. Psychology
Limbic system
Limbic System - metabolism
Maze Learning - physiology
Medical sciences
Mice
Mice, Inbred C57BL
Mice, Knockout
Neuropharmacology
Pharmacology. Drug treatments
Preproenkephalin knockout
Proto-Oncogene Proteins c-fos - metabolism
Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer
Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Psychopharmacology
Reaction Time - drug effects
Reaction Time - genetics
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Summary:Enkephalin-deficient knockout mice, a genetic model of enhanced anxiety responses, and wild-type controls were housed in two separate facilities on the same campus using different caging systems. Stress reactivity was evaluated in these animals using a zero-maze test followed by c-Fos expression analysis in limbic brain regions. Animals with genetically or pharmacologically enhanced anxiety reared and tested in the same facility displayed similar behavioral reactivity and c-Fos induction. However, we found much stronger anxiety-related behavioral responses and higher c-Fos levels when animals were house in individually ventilated cages, independent of their genetic background.
ISSN:0166-4328
1872-7549
DOI:10.1016/j.bbr.2007.08.027