Two Photon Polymerization of Polymer-Ceramic Hybrid Materials for Transdermal Drug Delivery

Three‐dimensional microneedle devices were created by femtosecond laser two photon polymerization (2PP) of organically modified ceramic (Ormocer®) hybrid materials. Arrays of in‐plane and out‐of‐plane hollow microneedles (microneedle length=800 μm, microneedle base diameter=150–300 μm) with various...

Full description

Saved in:
Bibliographic Details
Published in:International journal of applied ceramic technology 2007-01, Vol.4 (1), p.22-29
Main Authors: Ovsianikov, A., Chichkov, B., Mente, P., Monteiro-Riviere, N. A., Doraiswamy, A., Narayan, R. J.
Format: Article
Language:English
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Three‐dimensional microneedle devices were created by femtosecond laser two photon polymerization (2PP) of organically modified ceramic (Ormocer®) hybrid materials. Arrays of in‐plane and out‐of‐plane hollow microneedles (microneedle length=800 μm, microneedle base diameter=150–300 μm) with various aspect ratios were fabricated. The fracture and penetration properties of the microneedle arrays were examined using compression load testing. In these studies, the microneedle arrays penetrated cadaveric porcine adipose tissue without fracture. Human epidermal keratinocyte viability on the Ormocer® surfaces polymerized using 2PP was similar to that on control surfaces. These results suggest that 2PP is able to create microneedle structures for transdermal drug delivery with a larger range of geometries than conventional microfabrication techniques.
ISSN:1546-542X
1744-7402
DOI:10.1111/j.1744-7402.2007.02115.x