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Genotoxic Assessment of Different Sizes of Iron Oxide Nanoparticles and Ionic Iron in Earthworm (Eisenia hortensis) Coelomocytes by Comet Assay and Micronucleus Test
The current study was designed to evaluate genotoxicity of different sizes of iron oxide nanoparticles (IONPs) and ionic iron using coelomocytes of the earthworms Eisenia hortensis . Earthworms were exposed to different series of IONPs and ionic iron concentrations to find the respective LC50 of the...
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| Published in: | Bulletin of environmental contamination and toxicology 2018-07, Vol.101 (1), p.105-109 |
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| Main Authors: | , , , , |
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| container_title | Bulletin of environmental contamination and toxicology |
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| creator | Ciğerci, İbrahim Hakkı Ali, Muhammad Muddassir Kaygısız, Şöhret Yüksek Kaya, Bülent Liman, Recep |
| description | The current study was designed to evaluate genotoxicity of different sizes of iron oxide nanoparticles (IONPs) and ionic iron using coelomocytes of the earthworms
Eisenia hortensis
. Earthworms were exposed to different series of IONPs and ionic iron concentrations to find the respective LC50 of the chosen chemicals. LC
50
for |
| doi_str_mv | 10.1007/s00128-018-2364-y |
| format | article |
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Eisenia hortensis
. Earthworms were exposed to different series of IONPs and ionic iron concentrations to find the respective LC50 of the chosen chemicals. LC
50
for < 50, <100 nm and the ionic iron of IONPs were 500, 200, 250 µg/mL respectively. Concentrations of LC
50
/2 (250, 100, 125 µg/mL for < 50, <100 nm and the ionic iron respectively) and LC
50
for 48 h were used to perform the comet assay and micronucleus test. Statistically significant (
p
< 0.05) increase in DNA and chromosomal damage was observed for all sizes of IONPs and ionic iron. In the comet assay system, the greatest genotoxicity was observed in the treatments with < 100 nm IONPs, whereas the greatest numbers of micronuclei and binucleate cells were observed in the treatments with ionic iron. It was concluded that different types of nanoparticles (i.e. sizes, shapes) may have different genotoxic potencies in different assays with
E. hortensis
earthworms.]]></description><identifier>ISSN: 0007-4861</identifier><identifier>EISSN: 1432-0800</identifier><identifier>DOI: 10.1007/s00128-018-2364-y</identifier><identifier>PMID: 29802429</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Animals ; Aquatic Pollution ; Bioassays ; Chromosome aberrations ; Coelomocytes ; Comet Assay ; Damage detection ; Deoxyribonucleic acid ; DNA ; DNA damage ; DNA Damage - drug effects ; Earth and Environmental Science ; Ecotoxicology ; Eisenia hortensis ; Environment ; Environmental Chemistry ; Environmental Health ; Ferric Compounds - chemistry ; Ferric Compounds - toxicity ; Genotoxicity ; Ions - chemistry ; Ions - toxicity ; Iron oxides ; Micronuclei ; Micronucleus Tests ; Nanoparticles ; Nanoparticles - chemistry ; Nanoparticles - toxicity ; Oligochaeta ; Oligochaeta - drug effects ; Pollution ; Soil Science & Conservation ; Statistical analysis ; Waste Water Technology ; Water Management ; Water Pollution Control</subject><ispartof>Bulletin of environmental contamination and toxicology, 2018-07, Vol.101 (1), p.105-109</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2018</rights><rights>Bulletin of Environmental Contamination and Toxicology is a copyright of Springer, (2018). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-cdcb9e4e77cd48fa665157926d87d0cfe476b94ff937864d3b6ba14aee8021bf3</citedby><cites>FETCH-LOGICAL-c372t-cdcb9e4e77cd48fa665157926d87d0cfe476b94ff937864d3b6ba14aee8021bf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29802429$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ciğerci, İbrahim Hakkı</creatorcontrib><creatorcontrib>Ali, Muhammad Muddassir</creatorcontrib><creatorcontrib>Kaygısız, Şöhret Yüksek</creatorcontrib><creatorcontrib>Kaya, Bülent</creatorcontrib><creatorcontrib>Liman, Recep</creatorcontrib><title>Genotoxic Assessment of Different Sizes of Iron Oxide Nanoparticles and Ionic Iron in Earthworm (Eisenia hortensis) Coelomocytes by Comet Assay and Micronucleus Test</title><title>Bulletin of environmental contamination and toxicology</title><addtitle>Bull Environ Contam Toxicol</addtitle><addtitle>Bull Environ Contam Toxicol</addtitle><description><![CDATA[The current study was designed to evaluate genotoxicity of different sizes of iron oxide nanoparticles (IONPs) and ionic iron using coelomocytes of the earthworms
Eisenia hortensis
. Earthworms were exposed to different series of IONPs and ionic iron concentrations to find the respective LC50 of the chosen chemicals. LC
50
for < 50, <100 nm and the ionic iron of IONPs were 500, 200, 250 µg/mL respectively. Concentrations of LC
50
/2 (250, 100, 125 µg/mL for < 50, <100 nm and the ionic iron respectively) and LC
50
for 48 h were used to perform the comet assay and micronucleus test. Statistically significant (
p
< 0.05) increase in DNA and chromosomal damage was observed for all sizes of IONPs and ionic iron. In the comet assay system, the greatest genotoxicity was observed in the treatments with < 100 nm IONPs, whereas the greatest numbers of micronuclei and binucleate cells were observed in the treatments with ionic iron. It was concluded that different types of nanoparticles (i.e. sizes, shapes) may have different genotoxic potencies in different assays with
E. hortensis
earthworms.]]></description><subject>Animals</subject><subject>Aquatic Pollution</subject><subject>Bioassays</subject><subject>Chromosome aberrations</subject><subject>Coelomocytes</subject><subject>Comet Assay</subject><subject>Damage detection</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>DNA damage</subject><subject>DNA Damage - drug effects</subject><subject>Earth and Environmental Science</subject><subject>Ecotoxicology</subject><subject>Eisenia hortensis</subject><subject>Environment</subject><subject>Environmental Chemistry</subject><subject>Environmental Health</subject><subject>Ferric Compounds - chemistry</subject><subject>Ferric Compounds - toxicity</subject><subject>Genotoxicity</subject><subject>Ions - chemistry</subject><subject>Ions - toxicity</subject><subject>Iron oxides</subject><subject>Micronuclei</subject><subject>Micronucleus Tests</subject><subject>Nanoparticles</subject><subject>Nanoparticles - chemistry</subject><subject>Nanoparticles - toxicity</subject><subject>Oligochaeta</subject><subject>Oligochaeta - drug effects</subject><subject>Pollution</subject><subject>Soil Science & Conservation</subject><subject>Statistical analysis</subject><subject>Waste Water Technology</subject><subject>Water Management</subject><subject>Water Pollution Control</subject><issn>0007-4861</issn><issn>1432-0800</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp1kc9u1DAQxi0EotvCA3BBlri0h4DtePPnWC1LWanQA-UcOc6YukrsxZOoDe_DezLpFpCQOFnj-c332fMx9kqKt1KI8h0KIVWVCVllKi90Nj9hK6lzlYlKiKdsJQjKdFXII3aMeEv0ulLqOTtSdSWUVvWK_byAEMd47y0_RwTEAcLIo-PvvXOQluKL_wG4XO1SDPzq3nfAP5sQ9yaN3vbUM6HjuxhI4wHxgW-pd3MX08BPtx4heMNvYhohoMczvonQxyHaeaThdqZ6gHHxN_OD1idvSWci7Qn5NeD4gj1zpkd4-XiesK8fttebj9nl1cVuc36Z2bxUY2Y729agoSxtpytnimIt12Wtiq4qO2Ed6LJoa-1cnZdVobu8LVojtQGgdcjW5Sfs9KC7T_H7RMbN4NFC35sAccJGCb1WRU1LJPTNP-htnFKg1y2Ups2vZUmUPFD0IcQErtknP5g0N1I0S4bNIcOGMmyWDJuZZl4_Kk_tAN2fid-hEaAOAFIrfIP01_r_qr8AeVSp2g</recordid><startdate>20180701</startdate><enddate>20180701</enddate><creator>Ciğerci, İbrahim Hakkı</creator><creator>Ali, Muhammad Muddassir</creator><creator>Kaygısız, Şöhret Yüksek</creator><creator>Kaya, Bülent</creator><creator>Liman, Recep</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T7</scope><scope>7TK</scope><scope>7TV</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8C1</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>P64</scope><scope>PATMY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PYCSY</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20180701</creationdate><title>Genotoxic Assessment of Different Sizes of Iron Oxide Nanoparticles and Ionic Iron in Earthworm (Eisenia hortensis) Coelomocytes by Comet Assay and Micronucleus Test</title><author>Ciğerci, İbrahim Hakkı ; Ali, Muhammad Muddassir ; Kaygısız, Şöhret Yüksek ; Kaya, Bülent ; Liman, Recep</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-cdcb9e4e77cd48fa665157926d87d0cfe476b94ff937864d3b6ba14aee8021bf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Animals</topic><topic>Aquatic Pollution</topic><topic>Bioassays</topic><topic>Chromosome aberrations</topic><topic>Coelomocytes</topic><topic>Comet Assay</topic><topic>Damage detection</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>DNA damage</topic><topic>DNA Damage - drug effects</topic><topic>Earth and Environmental Science</topic><topic>Ecotoxicology</topic><topic>Eisenia hortensis</topic><topic>Environment</topic><topic>Environmental Chemistry</topic><topic>Environmental Health</topic><topic>Ferric Compounds - chemistry</topic><topic>Ferric Compounds - toxicity</topic><topic>Genotoxicity</topic><topic>Ions - chemistry</topic><topic>Ions - toxicity</topic><topic>Iron oxides</topic><topic>Micronuclei</topic><topic>Micronucleus Tests</topic><topic>Nanoparticles</topic><topic>Nanoparticles - chemistry</topic><topic>Nanoparticles - toxicity</topic><topic>Oligochaeta</topic><topic>Oligochaeta - drug effects</topic><topic>Pollution</topic><topic>Soil Science & Conservation</topic><topic>Statistical analysis</topic><topic>Waste Water Technology</topic><topic>Water Management</topic><topic>Water Pollution Control</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ciğerci, İbrahim Hakkı</creatorcontrib><creatorcontrib>Ali, Muhammad Muddassir</creatorcontrib><creatorcontrib>Kaygısız, Şöhret Yüksek</creatorcontrib><creatorcontrib>Kaya, Bülent</creatorcontrib><creatorcontrib>Liman, Recep</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Pollution Abstracts</collection><collection>Toxicology Abstracts</collection><collection>ProQuest - 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Academic</collection><jtitle>Bulletin of environmental contamination and toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ciğerci, İbrahim Hakkı</au><au>Ali, Muhammad Muddassir</au><au>Kaygısız, Şöhret Yüksek</au><au>Kaya, Bülent</au><au>Liman, Recep</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genotoxic Assessment of Different Sizes of Iron Oxide Nanoparticles and Ionic Iron in Earthworm (Eisenia hortensis) Coelomocytes by Comet Assay and Micronucleus Test</atitle><jtitle>Bulletin of environmental contamination and toxicology</jtitle><stitle>Bull Environ Contam Toxicol</stitle><addtitle>Bull Environ Contam Toxicol</addtitle><date>2018-07-01</date><risdate>2018</risdate><volume>101</volume><issue>1</issue><spage>105</spage><epage>109</epage><pages>105-109</pages><issn>0007-4861</issn><eissn>1432-0800</eissn><abstract><![CDATA[The current study was designed to evaluate genotoxicity of different sizes of iron oxide nanoparticles (IONPs) and ionic iron using coelomocytes of the earthworms
Eisenia hortensis
. Earthworms were exposed to different series of IONPs and ionic iron concentrations to find the respective LC50 of the chosen chemicals. LC
50
for < 50, <100 nm and the ionic iron of IONPs were 500, 200, 250 µg/mL respectively. Concentrations of LC
50
/2 (250, 100, 125 µg/mL for < 50, <100 nm and the ionic iron respectively) and LC
50
for 48 h were used to perform the comet assay and micronucleus test. Statistically significant (
p
< 0.05) increase in DNA and chromosomal damage was observed for all sizes of IONPs and ionic iron. In the comet assay system, the greatest genotoxicity was observed in the treatments with < 100 nm IONPs, whereas the greatest numbers of micronuclei and binucleate cells were observed in the treatments with ionic iron. It was concluded that different types of nanoparticles (i.e. sizes, shapes) may have different genotoxic potencies in different assays with
E. hortensis
earthworms.]]></abstract><cop>New York</cop><pub>Springer US</pub><pmid>29802429</pmid><doi>10.1007/s00128-018-2364-y</doi><tpages>5</tpages></addata></record> |
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| ispartof | Bulletin of environmental contamination and toxicology, 2018-07, Vol.101 (1), p.105-109 |
| issn | 0007-4861 1432-0800 |
| language | eng |
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| source | Springer Nature |
| subjects | Animals Aquatic Pollution Bioassays Chromosome aberrations Coelomocytes Comet Assay Damage detection Deoxyribonucleic acid DNA DNA damage DNA Damage - drug effects Earth and Environmental Science Ecotoxicology Eisenia hortensis Environment Environmental Chemistry Environmental Health Ferric Compounds - chemistry Ferric Compounds - toxicity Genotoxicity Ions - chemistry Ions - toxicity Iron oxides Micronuclei Micronucleus Tests Nanoparticles Nanoparticles - chemistry Nanoparticles - toxicity Oligochaeta Oligochaeta - drug effects Pollution Soil Science & Conservation Statistical analysis Waste Water Technology Water Management Water Pollution Control |
| title | Genotoxic Assessment of Different Sizes of Iron Oxide Nanoparticles and Ionic Iron in Earthworm (Eisenia hortensis) Coelomocytes by Comet Assay and Micronucleus Test |
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