Radioprotective Properties of Neomitilan in Experimental Radiation Pneumonia

The efficiency of neomitilan, a polysaccharide isolated from Crenomytilus grayanus mussels, was studied in experimental model of radiation pneumonia (irradiation of the animal lungs with a total dose of 14 and 28 Gy). Histological study showed that an increase in the number of nucleated components i...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2018-05, Vol.165 (1), p.40-43
Main Authors: Apanasevich, V. I., Plekhova, N. G., Lagureva, A. V., Goncharov, A. V., Kotsyurbii, E. A., Plotnikova, O. S., Sivoraksha, D. A., Tarakova, O. V., Molchanova, V. I., Luk’yanov, P. A.
Format: Article
Language:English
Subjects:
Administration, Inhalation
Analysis
Animals
Biomedical and Life Sciences
Biomedicine
Bivalvia - chemistry
Cell Biology
Dose-Response Relationship, Radiation
Female
Internal Medicine
Ionizing radiation
Laboratory Medicine
Mice
Pathology
Pharmacology and Toxicology
Pneumonia
Polysaccharides - chemistry
Polysaccharides - therapeutic use
Radiation Injuries, Experimental - drug therapy
Radiation Pneumonitis - drug therapy
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Summary:The efficiency of neomitilan, a polysaccharide isolated from Crenomytilus grayanus mussels, was studied in experimental model of radiation pneumonia (irradiation of the animal lungs with a total dose of 14 and 28 Gy). Histological study showed that an increase in the number of nucleated components in the lungs of animals subjected to neomitilan inhalation prior to irradiation. Proliferation of bronchial epitheliocytes and the formation of additional lymphoid structures were also revealed in these animals. The absence of a tendency to lung tissue recovery in animals irradiated with 28 Gy is due to extreme radiation toxicity.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-018-4094-x