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Radioprotective Properties of Neomitilan in Experimental Radiation Pneumonia
The efficiency of neomitilan, a polysaccharide isolated from Crenomytilus grayanus mussels, was studied in experimental model of radiation pneumonia (irradiation of the animal lungs with a total dose of 14 and 28 Gy). Histological study showed that an increase in the number of nucleated components i...
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| Published in: | Bulletin of experimental biology and medicine 2018-05, Vol.165 (1), p.40-43 |
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| container_end_page | 43 |
| container_issue | 1 |
| container_start_page | 40 |
| container_title | Bulletin of experimental biology and medicine |
| container_volume | 165 |
| creator | Apanasevich, V. I. Plekhova, N. G. Lagureva, A. V. Goncharov, A. V. Kotsyurbii, E. A. Plotnikova, O. S. Sivoraksha, D. A. Tarakova, O. V. Molchanova, V. I. Luk’yanov, P. A. |
| description | The efficiency of neomitilan, a polysaccharide isolated from
Crenomytilus grayanus
mussels, was studied in experimental model of radiation pneumonia (irradiation of the animal lungs with a total dose of 14 and 28 Gy). Histological study showed that an increase in the number of nucleated components in the lungs of animals subjected to neomitilan inhalation prior to irradiation. Proliferation of bronchial epitheliocytes and the formation of additional lymphoid structures were also revealed in these animals. The absence of a tendency to lung tissue recovery in animals irradiated with 28 Gy is due to extreme radiation toxicity. |
| doi_str_mv | 10.1007/s10517-018-4094-x |
| format | article |
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Crenomytilus grayanus
mussels, was studied in experimental model of radiation pneumonia (irradiation of the animal lungs with a total dose of 14 and 28 Gy). Histological study showed that an increase in the number of nucleated components in the lungs of animals subjected to neomitilan inhalation prior to irradiation. Proliferation of bronchial epitheliocytes and the formation of additional lymphoid structures were also revealed in these animals. The absence of a tendency to lung tissue recovery in animals irradiated with 28 Gy is due to extreme radiation toxicity.</description><identifier>ISSN: 0007-4888</identifier><identifier>EISSN: 1573-8221</identifier><identifier>DOI: 10.1007/s10517-018-4094-x</identifier><identifier>PMID: 29796814</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Administration, Inhalation ; Analysis ; Animals ; Biomedical and Life Sciences ; Biomedicine ; Bivalvia - chemistry ; Cell Biology ; Dose-Response Relationship, Radiation ; Female ; Internal Medicine ; Ionizing radiation ; Laboratory Medicine ; Mice ; Pathology ; Pharmacology and Toxicology ; Pneumonia ; Polysaccharides - chemistry ; Polysaccharides - therapeutic use ; Radiation Injuries, Experimental - drug therapy ; Radiation Pneumonitis - drug therapy</subject><ispartof>Bulletin of experimental biology and medicine, 2018-05, Vol.165 (1), p.40-43</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2018</rights><rights>COPYRIGHT 2018 Springer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c394t-e7d2d13032e16cb93f93d166795cff12f7f98117356fbc32c8b4c7161c7db5e03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,27911,27912</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29796814$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Apanasevich, V. I.</creatorcontrib><creatorcontrib>Plekhova, N. G.</creatorcontrib><creatorcontrib>Lagureva, A. V.</creatorcontrib><creatorcontrib>Goncharov, A. V.</creatorcontrib><creatorcontrib>Kotsyurbii, E. A.</creatorcontrib><creatorcontrib>Plotnikova, O. S.</creatorcontrib><creatorcontrib>Sivoraksha, D. A.</creatorcontrib><creatorcontrib>Tarakova, O. V.</creatorcontrib><creatorcontrib>Molchanova, V. I.</creatorcontrib><creatorcontrib>Luk’yanov, P. A.</creatorcontrib><title>Radioprotective Properties of Neomitilan in Experimental Radiation Pneumonia</title><title>Bulletin of experimental biology and medicine</title><addtitle>Bull Exp Biol Med</addtitle><addtitle>Bull Exp Biol Med</addtitle><description>The efficiency of neomitilan, a polysaccharide isolated from
Crenomytilus grayanus
mussels, was studied in experimental model of radiation pneumonia (irradiation of the animal lungs with a total dose of 14 and 28 Gy). Histological study showed that an increase in the number of nucleated components in the lungs of animals subjected to neomitilan inhalation prior to irradiation. Proliferation of bronchial epitheliocytes and the formation of additional lymphoid structures were also revealed in these animals. The absence of a tendency to lung tissue recovery in animals irradiated with 28 Gy is due to extreme radiation toxicity.</description><subject>Administration, Inhalation</subject><subject>Analysis</subject><subject>Animals</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Bivalvia - chemistry</subject><subject>Cell Biology</subject><subject>Dose-Response Relationship, Radiation</subject><subject>Female</subject><subject>Internal Medicine</subject><subject>Ionizing radiation</subject><subject>Laboratory Medicine</subject><subject>Mice</subject><subject>Pathology</subject><subject>Pharmacology and Toxicology</subject><subject>Pneumonia</subject><subject>Polysaccharides - chemistry</subject><subject>Polysaccharides - therapeutic use</subject><subject>Radiation Injuries, Experimental - drug therapy</subject><subject>Radiation Pneumonitis - drug therapy</subject><issn>0007-4888</issn><issn>1573-8221</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp9kV1rFTEQhoMo9lj9Ad7IgiDebM3kY7N7WUr9gIMW0euQzU7alN3kuMmW4783y1axIJKLkJnnHSbvS8hLoGdAqXqXgEpQNYW2FrQT9fER2YFUvG4Zg8dkRwtUi7ZtT8izlG7XJ23gKTlhneqaFsSO7L-awcfDHDPa7O-wuprjAefsMVXRVZ8xTj770YTKh-ryWFp-wpDNWK1Ck30M1VXAZYrBm-fkiTNjwhf39yn5_v7y28XHev_lw6eL831teSdyjWpgA3DKGUJj-467jg_QNKqT1jlgTrmuBVBcNq63nNm2F1ZBA1YNvUTKT8nbbW7Z-8eCKevJJ4tjWRPjkjSjQjLFOoCCvt7QazOi9sHFPBu74vpcCiEBJBeFOvsHVc6Ak7cxoPOl_kDw5i_BDZox36Q4Lqsf6SEIG2jnmNKMTh-Kg2b-qYHqNUS9hahLiHoNUR-L5tX995Z-wuGP4ndqBWAbkEorXOOsb-Myh2L5f6b-AoY9pb8</recordid><startdate>20180501</startdate><enddate>20180501</enddate><creator>Apanasevich, V. 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| subjects | Administration, Inhalation Analysis Animals Biomedical and Life Sciences Biomedicine Bivalvia - chemistry Cell Biology Dose-Response Relationship, Radiation Female Internal Medicine Ionizing radiation Laboratory Medicine Mice Pathology Pharmacology and Toxicology Pneumonia Polysaccharides - chemistry Polysaccharides - therapeutic use Radiation Injuries, Experimental - drug therapy Radiation Pneumonitis - drug therapy |
| title | Radioprotective Properties of Neomitilan in Experimental Radiation Pneumonia |
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