Visible-light-activated photoCORMs: rational design of CO-releasing organic molecules absorbing in the tissue-transparent window

To date, most known molecules that release carbon monoxide by the action of light are based on carbonyl complexes of metals. However, they suffer from several disadvantages, so the focus of this perspective is on photoactivatable metal-free CO precursors. The development and design of these systems...

Full description

Saved in:
Bibliographic Details
Published in:Photochemical & photobiological sciences 2018, Vol.17 (6), p.692-71
Main Authors: Slanina, Tomáš, Šebej, Peter
Format: Article
Language:English
Subjects:
Biochemistry
Biocompatibility
Biomaterials
Carbon monoxide
Carbonyls
Chemistry
Coordination compounds
Design
Hydrophobicity
Metals
Molecular chains
Organic chemistry
Perspective
Physical Chemistry
Plant Sciences
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:To date, most known molecules that release carbon monoxide by the action of light are based on carbonyl complexes of metals. However, they suffer from several disadvantages, so the focus of this perspective is on photoactivatable metal-free CO precursors. The development and design of these systems from the starting point of deep-UV-absorbing hydrophobic molecules and leading to hydrophilic biocompatible visible-light-absorbing CO-releasing molecules (photoCORMs) is described with mechanistic details for several structural motifs. The possibilities of this development are not exhausted and here we discuss the design of new biologically interesting candidates. Rational design of visible-light-activatable transition-metal-free CO-releasing molecules with an emphasis on mechanistic details of the CO release.
ISSN:1474-905X
1474-9092
DOI:10.1039/c8pp00096d