The role of the maternal and fetal inflammatory response in retinopathy of prematurity

Problem There is a paucity of research on the contribution of placental inflammation to severe retinopathy of prematurity (ROP). Method of Study A retrospective cohort study (n = 1217) was conducted of infants screened for ROP (2006‐2016). The outcomes of the study were severe ROP (type 1 or type 2...

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Bibliographic Details
Published in:American journal of reproductive immunology (1989) 2018-09, Vol.80 (3), p.e12986-n/a
Main Authors: Lynch, Anne M., Berning, Amber A., Thevarajah, Tamara S., Wagner, Brandie D., Post, Miriam D., McCourt, Emily A., Cathcart, Jennifer N., Hodges, Jennifer K., Mandava, Naresh, Gibbs, Ronald S., Palestine, Alan G.
Format: Article
Language:English
Subjects:
Data processing
fetal inflammatory response
Fetuses
Infants
Inflammation
maternal inflammatory response
Placenta
Premature birth
preterm birth
Retinopathy
retinopathy of prematurity
subtypes of preterm birth
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Summary:Problem There is a paucity of research on the contribution of placental inflammation to severe retinopathy of prematurity (ROP). Method of Study A retrospective cohort study (n = 1217) was conducted of infants screened for ROP (2006‐2016). The outcomes of the study were severe ROP (type 1 or type 2 ROP) and low grade ROP. We categorized the placental pathology as the presence of (i) maternal plus fetal inflammatory response, (ii) maternal inflammatory response only, (iii) fetal inflammatory response only and, (iv) no evidence of a maternal or fetal inflammatory response. The data were analyzed using univariate and multivariate logistic regression analyses (P 
ISSN:1046-7408
1600-0897
DOI:10.1111/aji.12986