Evaluation of coronary features of HIV patients presenting with ACS: The CUORE, a multicenter study

The risk of recurrence of myocardial infarction (MI) in HIV patients presenting with acute coronary syndrome (ACS) is well known, but there is limited evidence about potential differences in coronary plaques compared to non-HIV patients. In this multicenter case-control study, HIV patients presentin...

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Bibliographic Details
Published in:Atherosclerosis 2018-07, Vol.274, p.218-226
Main Authors: Peyracchia, Mattia, De Lio, Giulia, Montrucchio, Chiara, Omedè, Pierluigi, d’Ettore, Gabriella, Calcagno, Andrea, Vullo, Vincenzo, Cerrato, Enrico, Pennacchi, Mauro, Sardella, Gennaro, Manga, Pravin, GrossoMarra, Walter, Vullo, Francesco, Fedele, Francesco, Biondi-Zoccai, Giuseppe, Moretti, Claudio, Vachiat, Ahmed, Bonora, Stefano, Rinaldi, Mauro, Mancone, Massimo, D'Ascenzo, Fabrizio
Format: Article
Language:English
Subjects:
Acute Coronary Syndrome - diagnostic imaging
Acute Coronary Syndrome - epidemiology
Acute Coronary Syndrome - mortality
Acute Coronary Syndrome - physiopathology
Aged
Antiretroviral Therapy, Highly Active
Coronary Angiography
Coronary Artery Disease - diagnostic imaging
Coronary Artery Disease - epidemiology
Coronary Artery Disease - mortality
Coronary Artery Disease - physiopathology
Coronary Vessels - diagnostic imaging
Coronary Vessels - physiopathology
Female
HIV Infections - diagnosis
HIV Infections - drug therapy
HIV Infections - epidemiology
HIV Infections - mortality
Humans
Incidence
Italy - epidemiology
Male
Middle Aged
Plaque, Atherosclerotic
Predictive Value of Tests
Prevalence
Prognosis
Retrospective Studies
Risk Assessment
Risk Factors
Time Factors
Ultrasonography, Interventional
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Summary:The risk of recurrence of myocardial infarction (MI) in HIV patients presenting with acute coronary syndrome (ACS) is well known, but there is limited evidence about potential differences in coronary plaques compared to non-HIV patients. In this multicenter case-control study, HIV patients presenting with ACS, with intravascular-ultrasound (IVUS) data, enrolled between February 2015 and June 2017, and undergoing highly active antiretroviral therapy (HAART), were retrospectively compared to non-HIV patients presenting with ACS, before and after propensity score with matching, randomly selected from included centers. Primary end-point was the prevalence of multivessel disease. Secondary end-points were the prevalence of abnormal features at IVUS, the incidence of major-acute-cardiovascular-events (MACE), a composite end point of cardiovascular death, MI, target lesion revascularization (TLR), stent thrombosis (ST), non-cardiac death and target vessel revascularization (TVR). For each end-point, a subgroup analysis was conducted in HIV patients with CD4 cell count
ISSN:0021-9150
1879-1484
DOI:10.1016/j.atherosclerosis.2018.05.001