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Economic burden of seasonal influenza in the United States
Seasonal influenza is responsible for a large disease and economic burden. Despite the expanding recommendation of influenza vaccination, influenza has continued to be a major public health concern in the United States (U.S.). To evaluate influenza prevention strategies it is important that policy m...
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| Published in: | Vaccine 2018-06, Vol.36 (27), p.3960-3966 |
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| Main Authors: | , , , |
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| container_end_page | 3966 |
| container_issue | 27 |
| container_start_page | 3960 |
| container_title | Vaccine |
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| creator | Putri, Wayan C.W.S. Muscatello, David J. Stockwell, Melissa S. Newall, Anthony T. |
| description | Seasonal influenza is responsible for a large disease and economic burden. Despite the expanding recommendation of influenza vaccination, influenza has continued to be a major public health concern in the United States (U.S.). To evaluate influenza prevention strategies it is important that policy makers have current estimates of the economic burden of influenza.
To provide an updated estimate of the average annual economic burden of seasonal influenza in the U.S. population in the presence of vaccination efforts.
We evaluated estimates of age-specific influenza-attributable outcomes (ill-non medically attended, office-based outpatient visit, emergency department visits, hospitalizations and death) and associated productivity loss. Health outcome rates were applied to the 2015 U.S. population and multiplied by the relevant estimated unit costs for each outcome. We evaluated both direct healthcare costs and indirect costs (absenteeism from paid employment) reporting results from both a healthcare system and societal perspective. Results were presented in five age groups ( |
| doi_str_mv | 10.1016/j.vaccine.2018.05.057 |
| format | article |
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To provide an updated estimate of the average annual economic burden of seasonal influenza in the U.S. population in the presence of vaccination efforts.
We evaluated estimates of age-specific influenza-attributable outcomes (ill-non medically attended, office-based outpatient visit, emergency department visits, hospitalizations and death) and associated productivity loss. Health outcome rates were applied to the 2015 U.S. population and multiplied by the relevant estimated unit costs for each outcome. We evaluated both direct healthcare costs and indirect costs (absenteeism from paid employment) reporting results from both a healthcare system and societal perspective. Results were presented in five age groups (<5 years, 5–17 years, 18–49 years, 50–64 years and ≥65 years of age).
The estimated average annual total economic burden of influenza to the healthcare system and society was $11.2 billion ($6.3–$25.3 billion). Direct medical costs were estimated to be $3.2 billion ($1.5–$11.7 billion) and indirect costs $8.0 billion ($4.8–$13.6 billion). These total costs were based on the estimated average numbers of (1) ill-non medically attended patients (21.6 million), (2) office-based outpatient visits (3.7 million), (3) emergency department visit (0.65 million) (4) hospitalizations (247.0 thousand), (5) deaths (36.3 thousand) and (6) days of productivity lost (20.1 million).
This study provides an updated estimate of the total economic burden of influenza in the U.S. Although we found a lower total cost than previously estimated, our results confirm that influenza is responsible for a substantial economic burden in the U.S.</description><identifier>ISSN: 0264-410X</identifier><identifier>EISSN: 1873-2518</identifier><identifier>DOI: 10.1016/j.vaccine.2018.05.057</identifier><identifier>PMID: 29801998</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Absenteeism ; Age ; Age groups ; Cost-of-illness ; Disease burden ; Economic burden ; Economic conditions ; Economics ; Emergency medical services ; Estimates ; Health care ; Health care expenditures ; Hospitalization ; Illnesses ; Immunization ; Infections ; Influenza ; Laboratories ; Population ; Productivity ; Public health ; Sensitivity analysis ; Time series ; Vaccination</subject><ispartof>Vaccine, 2018-06, Vol.36 (27), p.3960-3966</ispartof><rights>2018 Elsevier Ltd</rights><rights>Copyright © 2018. Published by Elsevier Ltd.</rights><rights>Copyright Elsevier Limited Jun 22, 2018</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c459t-6571d34b459514eb8c02e09c2ffc75f6c12d68624887a5eb256334d69ffa90243</citedby><cites>FETCH-LOGICAL-c459t-6571d34b459514eb8c02e09c2ffc75f6c12d68624887a5eb256334d69ffa90243</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29801998$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Putri, Wayan C.W.S.</creatorcontrib><creatorcontrib>Muscatello, David J.</creatorcontrib><creatorcontrib>Stockwell, Melissa S.</creatorcontrib><creatorcontrib>Newall, Anthony T.</creatorcontrib><title>Economic burden of seasonal influenza in the United States</title><title>Vaccine</title><addtitle>Vaccine</addtitle><description>Seasonal influenza is responsible for a large disease and economic burden. Despite the expanding recommendation of influenza vaccination, influenza has continued to be a major public health concern in the United States (U.S.). To evaluate influenza prevention strategies it is important that policy makers have current estimates of the economic burden of influenza.
To provide an updated estimate of the average annual economic burden of seasonal influenza in the U.S. population in the presence of vaccination efforts.
We evaluated estimates of age-specific influenza-attributable outcomes (ill-non medically attended, office-based outpatient visit, emergency department visits, hospitalizations and death) and associated productivity loss. Health outcome rates were applied to the 2015 U.S. population and multiplied by the relevant estimated unit costs for each outcome. We evaluated both direct healthcare costs and indirect costs (absenteeism from paid employment) reporting results from both a healthcare system and societal perspective. Results were presented in five age groups (<5 years, 5–17 years, 18–49 years, 50–64 years and ≥65 years of age).
The estimated average annual total economic burden of influenza to the healthcare system and society was $11.2 billion ($6.3–$25.3 billion). Direct medical costs were estimated to be $3.2 billion ($1.5–$11.7 billion) and indirect costs $8.0 billion ($4.8–$13.6 billion). These total costs were based on the estimated average numbers of (1) ill-non medically attended patients (21.6 million), (2) office-based outpatient visits (3.7 million), (3) emergency department visit (0.65 million) (4) hospitalizations (247.0 thousand), (5) deaths (36.3 thousand) and (6) days of productivity lost (20.1 million).
This study provides an updated estimate of the total economic burden of influenza in the U.S. Although we found a lower total cost than previously estimated, our results confirm that influenza is responsible for a substantial economic burden in the U.S.</description><subject>Absenteeism</subject><subject>Age</subject><subject>Age groups</subject><subject>Cost-of-illness</subject><subject>Disease burden</subject><subject>Economic burden</subject><subject>Economic conditions</subject><subject>Economics</subject><subject>Emergency medical services</subject><subject>Estimates</subject><subject>Health care</subject><subject>Health care expenditures</subject><subject>Hospitalization</subject><subject>Illnesses</subject><subject>Immunization</subject><subject>Infections</subject><subject>Influenza</subject><subject>Laboratories</subject><subject>Population</subject><subject>Productivity</subject><subject>Public health</subject><subject>Sensitivity analysis</subject><subject>Time 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Limited</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7RV</scope><scope>7T2</scope><scope>7T5</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88C</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0R</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2O</scope><scope>M7N</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20180622</creationdate><title>Economic 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health</topic><topic>Sensitivity analysis</topic><topic>Time series</topic><topic>Vaccination</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Putri, Wayan C.W.S.</creatorcontrib><creatorcontrib>Muscatello, David J.</creatorcontrib><creatorcontrib>Stockwell, Melissa S.</creatorcontrib><creatorcontrib>Newall, Anthony T.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>ProQuest Nursing and Allied Health Source</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>ProQuest Health and Medical</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Healthcare Administration Database 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States</atitle><jtitle>Vaccine</jtitle><addtitle>Vaccine</addtitle><date>2018-06-22</date><risdate>2018</risdate><volume>36</volume><issue>27</issue><spage>3960</spage><epage>3966</epage><pages>3960-3966</pages><issn>0264-410X</issn><eissn>1873-2518</eissn><abstract>Seasonal influenza is responsible for a large disease and economic burden. Despite the expanding recommendation of influenza vaccination, influenza has continued to be a major public health concern in the United States (U.S.). To evaluate influenza prevention strategies it is important that policy makers have current estimates of the economic burden of influenza.
To provide an updated estimate of the average annual economic burden of seasonal influenza in the U.S. population in the presence of vaccination efforts.
We evaluated estimates of age-specific influenza-attributable outcomes (ill-non medically attended, office-based outpatient visit, emergency department visits, hospitalizations and death) and associated productivity loss. Health outcome rates were applied to the 2015 U.S. population and multiplied by the relevant estimated unit costs for each outcome. We evaluated both direct healthcare costs and indirect costs (absenteeism from paid employment) reporting results from both a healthcare system and societal perspective. Results were presented in five age groups (<5 years, 5–17 years, 18–49 years, 50–64 years and ≥65 years of age).
The estimated average annual total economic burden of influenza to the healthcare system and society was $11.2 billion ($6.3–$25.3 billion). Direct medical costs were estimated to be $3.2 billion ($1.5–$11.7 billion) and indirect costs $8.0 billion ($4.8–$13.6 billion). These total costs were based on the estimated average numbers of (1) ill-non medically attended patients (21.6 million), (2) office-based outpatient visits (3.7 million), (3) emergency department visit (0.65 million) (4) hospitalizations (247.0 thousand), (5) deaths (36.3 thousand) and (6) days of productivity lost (20.1 million).
This study provides an updated estimate of the total economic burden of influenza in the U.S. Although we found a lower total cost than previously estimated, our results confirm that influenza is responsible for a substantial economic burden in the U.S.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>29801998</pmid><doi>10.1016/j.vaccine.2018.05.057</doi><tpages>7</tpages></addata></record> |
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| issn | 0264-410X 1873-2518 |
| language | eng |
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| source | Elsevier |
| subjects | Absenteeism Age Age groups Cost-of-illness Disease burden Economic burden Economic conditions Economics Emergency medical services Estimates Health care Health care expenditures Hospitalization Illnesses Immunization Infections Influenza Laboratories Population Productivity Public health Sensitivity analysis Time series Vaccination |
| title | Economic burden of seasonal influenza in the United States |
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