Genome characteristics dictate poly-R-(3)-hydroxyalkanoate production in Cupriavidus necator H16

Cupriavidus necator H16 is a well-recognized enterprise with efficient manufacturing machineries to produce diverse polymers belonging to polyhydroxyalkanoates (PHAs) family. The genome fingerprints, including PHA machinery proteins and fatty acid metabolism, had educated engineering strategies to e...

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Bibliographic Details
Published in:World journal of microbiology & biotechnology 2018-06, Vol.34 (6), p.79-23, Article 79
Main Authors: Kutralam-Muniasamy, Gurusamy, Peréz-Guevara, Fermín
Format: Article
Language:English
Subjects:
Applied Microbiology
Biochemistry
Biomedical and Life Sciences
Biotechnology
Cupriavidus necator
Environmental Engineering/Biotechnology
Fermentation
Genomes
Knowledge acquisition
Life Sciences
Metabolic engineering
Metabolism
Microbiology
Monomers
Polyhydroxyalkanoates
Polymers
Proteins
Review
Substrates
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Summary:Cupriavidus necator H16 is a well-recognized enterprise with efficient manufacturing machineries to produce diverse polymers belonging to polyhydroxyalkanoates (PHAs) family. The genome fingerprints, including PHA machinery proteins and fatty acid metabolism, had educated engineering strategies to enhance PHAs production. This outstanding progress has enlightened us to present an exhaustive examination of the ongoing research, addressing the great potential design of genome features towards PHA production and furthermore, we show how those acquired knowledge have been explored in other biotechnological applications. This updated-review concludes that the combination of an optimal strain selection, suitable metabolic engineering and a large-scale fermentation on oil substrates is critical to endow the ability of incorporating mcl-PHAs monomers in this organism. Graphical Abstract
ISSN:0959-3993
1573-0972
DOI:10.1007/s11274-018-2460-5