DNA topoisomerase I and IIα expression in penile carcinomas: assessing potential tumour chemosensitivity

OBJECTIVE To examine the tissue expression of DNA topoisomerase I (Topo I) and IIα (Topo II), to pursue the possibility of future chemotherapy regimens for squamous cell carcinoma of the penis (SCCP), as high expression of Topo I might indicate sensitivity to the camptothecins, whereas high Topo II...

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Bibliographic Details
Published in:BJU international 2008-10, Vol.102 (8), p.1040-1044
Main Authors: Berney, Daniel M., Stankiewicz, Elzbieta, Adlan, Ahmed M.A., Kudahetti, Sakunthala, Biedrzycki, Olaf J., Hadway, Paul, Watkin, Nick, Corbishley, Cathy
Format: Article
Language:English
Subjects:
Antineoplastic agents
Biological and medical sciences
carcinoma
Chemotherapy
Medical sciences
Nephrology. Urinary tract diseases
penis
Pharmacology. Drug treatments
topoisomerase
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Summary:OBJECTIVE To examine the tissue expression of DNA topoisomerase I (Topo I) and IIα (Topo II), to pursue the possibility of future chemotherapy regimens for squamous cell carcinoma of the penis (SCCP), as high expression of Topo I might indicate sensitivity to the camptothecins, whereas high Topo II might indicate sensitivity to etoposide. PATIENTS AND METHODS In all, 73 patients with SCCP were reviewed and then tissue samples microarrayed. These were then stained with immunohistochemistry for Topo I, Topo II and Ki‐67. Tumour stage, grade and type were available. RESULTS Topo II showed a strong positive correlation with the proliferation index as measured by Ki‐67 (P 
ISSN:1464-4096
1464-410X
DOI:10.1111/j.1464-410X.2008.07698.x