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Two-stage controlled release system possesses excellent initial and long-term efficacy
[Display omitted] •Constructing two-stage controlled release system based on size distribution.•The pesticide delivery behavior was studied based on MCs formulations system.•The controlled release system provides excellent initial and long-term efficacy.•The release system is easy in technology and...
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Published in: | Colloids and surfaces, B, Biointerfaces B, Biointerfaces, 2018-09, Vol.169, p.404-410 |
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Main Authors: | , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | [Display omitted]
•Constructing two-stage controlled release system based on size distribution.•The pesticide delivery behavior was studied based on MCs formulations system.•The controlled release system provides excellent initial and long-term efficacy.•The release system is easy in technology and has great potential in other fields.
In this work, a series of polyurea-based lambda-cyhalothrin-loaded microcapsules (MCs) with three different size distributions (average diameters of 1.35 μm, MC-S; 5.13 μm, MC-M; and 21.48 μm, MC-L) were prepared and characterized. The results indicated that MCs with a smaller particle size distribution had a faster release rate and excellent initial efficacy against pests. MC-L had a remarkably slow incipient release rate, outstanding photostability and better later-stage efficacy than that of the other tested MCs. The results clarified that the diameter distribution of MCs is the key factor in determining the release property and bioactivity of the MC formulations. Subsequently, the binary mixture MC formulations of MC(+M), MC(S+L) and MC(M+L) were obtained by mixing MC-S, MC-M or MC-L at 1:1 to establish a two-stage release system utilized for foliar application situations. Greenhouse and field experiments showed that MC(S+L) provided an optimal efficacy, and its effective duration was much longer than that of the emulsifiable concentrate (EC) group. Therefore, the release system established in this study was simple and workable for regulating the initial and long-term efficacy by adjusting the particle size distribution; in addition, this system has potential applications in other fields such as drug delivery devices. |
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ISSN: | 0927-7765 1873-4367 |
DOI: | 10.1016/j.colsurfb.2018.05.023 |