Leptin replacement alters brain response to food cues in genetically leptin-deficient adults

A missense mutation in the ob gene causes leptin deficiency and morbid obesity. Leptin replacement to three adults with this mutation normalized body weight and eating behavior. Because the neural circuits mediating these changes were unknown, we paired functional magnetic resonance imaging (fMRI) w...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 2007-11, Vol.104 (46), p.18276-18279
Main Authors: Baicy, Kate, London, Edythe D, Monterosso, John, Wong, Ma-Li, Delibasi, Tuncay, Sharma, Anil, Licinio, Julio
Format: Article
Language:English
Subjects:
Biological Sciences
Body mass index
Brain
Brain - drug effects
Brain - physiology
Cerebellum
Coordinate systems
eating habits
Famine
Feeding Behavior - drug effects
food-related stimuli
foods
functional magnetic resonace imaging
genes
Genetic mutation
Humans
Hunger
leptin
Leptin - administration & dosage
Leptin - pharmacology
Magnetic Resonance Imaging
missense mutation
Mutation
neurophysiology
NMR
Nuclear magnetic resonance
ob gene
Obesity
Peptides
Prefrontal cortex
subcutaneous injection
visual stimuli
Z score
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Summary:A missense mutation in the ob gene causes leptin deficiency and morbid obesity. Leptin replacement to three adults with this mutation normalized body weight and eating behavior. Because the neural circuits mediating these changes were unknown, we paired functional magnetic resonance imaging (fMRI) with presentation of food cues to these subjects. During viewing of food-related stimuli, leptin replacement reduced brain activation in regions linked to hunger (insula, parietal and temporal cortex) while enhancing activation in regions linked to inhibition and satiety (prefrontal cortex). Leptin appears to modulate feeding behavior through these circuits, suggesting therapeutic targets for human obesity.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.0706481104