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Leptin replacement alters brain response to food cues in genetically leptin-deficient adults
A missense mutation in the ob gene causes leptin deficiency and morbid obesity. Leptin replacement to three adults with this mutation normalized body weight and eating behavior. Because the neural circuits mediating these changes were unknown, we paired functional magnetic resonance imaging (fMRI) w...
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| Published in: | Proceedings of the National Academy of Sciences - PNAS 2007-11, Vol.104 (46), p.18276-18279 |
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| Main Authors: | , , , , , , |
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| Language: | English |
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| cites | cdi_FETCH-LOGICAL-c620t-110d2248e200be3e16cc1216f10b4c610feffcc636180fb85e5ae664b15923a43 |
| container_end_page | 18279 |
| container_issue | 46 |
| container_start_page | 18276 |
| container_title | Proceedings of the National Academy of Sciences - PNAS |
| container_volume | 104 |
| creator | Baicy, Kate London, Edythe D Monterosso, John Wong, Ma-Li Delibasi, Tuncay Sharma, Anil Licinio, Julio |
| description | A missense mutation in the ob gene causes leptin deficiency and morbid obesity. Leptin replacement to three adults with this mutation normalized body weight and eating behavior. Because the neural circuits mediating these changes were unknown, we paired functional magnetic resonance imaging (fMRI) with presentation of food cues to these subjects. During viewing of food-related stimuli, leptin replacement reduced brain activation in regions linked to hunger (insula, parietal and temporal cortex) while enhancing activation in regions linked to inhibition and satiety (prefrontal cortex). Leptin appears to modulate feeding behavior through these circuits, suggesting therapeutic targets for human obesity. |
| doi_str_mv | 10.1073/pnas.0706481104 |
| format | article |
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Leptin replacement to three adults with this mutation normalized body weight and eating behavior. Because the neural circuits mediating these changes were unknown, we paired functional magnetic resonance imaging (fMRI) with presentation of food cues to these subjects. During viewing of food-related stimuli, leptin replacement reduced brain activation in regions linked to hunger (insula, parietal and temporal cortex) while enhancing activation in regions linked to inhibition and satiety (prefrontal cortex). 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Leptin replacement to three adults with this mutation normalized body weight and eating behavior. Because the neural circuits mediating these changes were unknown, we paired functional magnetic resonance imaging (fMRI) with presentation of food cues to these subjects. During viewing of food-related stimuli, leptin replacement reduced brain activation in regions linked to hunger (insula, parietal and temporal cortex) while enhancing activation in regions linked to inhibition and satiety (prefrontal cortex). Leptin appears to modulate feeding behavior through these circuits, suggesting therapeutic targets for human obesity.</description><subject>Biological Sciences</subject><subject>Body mass index</subject><subject>Brain</subject><subject>Brain - drug effects</subject><subject>Brain - physiology</subject><subject>Cerebellum</subject><subject>Coordinate systems</subject><subject>eating habits</subject><subject>Famine</subject><subject>Feeding Behavior - drug effects</subject><subject>food-related stimuli</subject><subject>foods</subject><subject>functional magnetic resonace imaging</subject><subject>genes</subject><subject>Genetic mutation</subject><subject>Humans</subject><subject>Hunger</subject><subject>leptin</subject><subject>Leptin - administration & dosage</subject><subject>Leptin - pharmacology</subject><subject>Magnetic Resonance Imaging</subject><subject>missense mutation</subject><subject>Mutation</subject><subject>neurophysiology</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>ob gene</subject><subject>Obesity</subject><subject>Peptides</subject><subject>Prefrontal cortex</subject><subject>subcutaneous injection</subject><subject>visual stimuli</subject><subject>Z score</subject><issn>0027-8424</issn><issn>1091-6490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><recordid>eNqFks1v1DAQxS0EosvCmRMQcUDikHbGcbzOpRKqWkBaiQP0hmQ53vGSlTcOdoLof4_3Q13gUl98eL95mudnxl4inCMsqouhN-kcFiCFQgTxiM0QGiylaOAxmwHwRakEF2fsWUobAGhqBU_ZGS4aJSXyGfu-pGHs-iLS4I2lLfVjYfxIMRVtNHshDaFPVIyhcCGsCjtRKrKwpp7Gzhrv7wq_NylX5Drb7S1Wkx_Tc_bEGZ_oxfGes9ub629Xn8rll4-frz4sSys5jGXefMW5UMQBWqoIpbXIUTqEVliJ4Mg5a2UlUYFrVU21ISlFi3XDKyOqObs8-A5Tu6WVzRtE4_UQu62JdzqYTv-r9N0PvQ6_NAclqnzm7N3RIIafOd-ot12y5L3pKUxJS1WDbJqHQQ5CAkrI4Nv_wE2YYp9fITMoeMMVZujiANkYUork7ldG0Lt-9a5ffeo3T7z-O-mJPxaageII7CZPdkILqVHxhczI-wcQ7Saf_8DvMbOvDuwmjSHew7wWNQjcxXxz0J0J2qxjl_Tt1xywAlBcAVfVHxc_zXc</recordid><startdate>20071113</startdate><enddate>20071113</enddate><creator>Baicy, Kate</creator><creator>London, Edythe D</creator><creator>Monterosso, John</creator><creator>Wong, Ma-Li</creator><creator>Delibasi, Tuncay</creator><creator>Sharma, Anil</creator><creator>Licinio, Julio</creator><general>National Academy of Sciences</general><general>National Acad Sciences</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20071113</creationdate><title>Leptin replacement alters brain response to food cues in genetically leptin-deficient adults</title><author>Baicy, Kate ; 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| ispartof | Proceedings of the National Academy of Sciences - PNAS, 2007-11, Vol.104 (46), p.18276-18279 |
| issn | 0027-8424 1091-6490 |
| language | eng |
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| source | JSTOR Archival Journals; PubMed Central |
| subjects | Biological Sciences Body mass index Brain Brain - drug effects Brain - physiology Cerebellum Coordinate systems eating habits Famine Feeding Behavior - drug effects food-related stimuli foods functional magnetic resonace imaging genes Genetic mutation Humans Hunger leptin Leptin - administration & dosage Leptin - pharmacology Magnetic Resonance Imaging missense mutation Mutation neurophysiology NMR Nuclear magnetic resonance ob gene Obesity Peptides Prefrontal cortex subcutaneous injection visual stimuli Z score |
| title | Leptin replacement alters brain response to food cues in genetically leptin-deficient adults |
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